A Prospective, Single-Arm Multi-Center Study of the HARMONIC® 1100 Shears in Select Devices

Inclusion Criteria:

Pediatric population:

1. Non-emergent procedure (general) where at least one vessel is planned to betransected by the HARMONIC 1100 Shears per the IFU;

2. Less than 18 years of age at the time of procedure; and

3. The subject's parent/legal guardian must be willing to give permission for thesubject to participate in the study and provide written informed consent for thesubject. In addition, assent must be obtained from pediatric subjects who possessthe intellectual and emotional ability to comprehend the concepts involved in thestudy. If the pediatric subject is not able to provide assent (due to age, maturityand/or inability to intellectually and/or emotionally comprehend the study), theparent/legal guardian's written informed consent for the subject will be acceptablefor the subject to be included in the study.

Adult population:

1. Elective procedure (general, gynecological, urological, or thoracic) where at leastone vessel is planned to be transected by the HARMONIC 1100 Shears per the IFU;

2. Willingness to give consent and comply with all study-related evaluations and visitschedule; and

3. At least 18 years of age.

Exclusion Criteria:

Preoperative

1. Physical or psychological condition which would impair study participation;

2. Female subjects, of childbearing age, who are pregnant; or

3. Enrollment in a concurrent interventional clinical study that could impact the studyendpoints.

Intraoperative

1. The HARMONIC 1100 Shears were not attempted to be used for at least one singlevessel transection during the surgical procedure.