Phase
Condition
Atopic Dermatitis
Allergy
Allergies & Asthma
Treatment
vehicle cream
tapinarof cream, 1%
Clinical Study ID
Ages > 2 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Male and female subjects ages 2 and above with clinical diagnosis of AD
Subject with atopic dermatitis covering ≥5% and ≤ 35% of the BSA
A vIGA-AD score of ≥3 at screening and baseline
An EASI score of ≥6 at screening and baseline
Atopic dermatitis present for at least 6 months for ages 6 years old and above or 3months for ages 2 to 5 years old
Female subjects of childbearing potential who are engaging in sexual activity thatcould lead to pregnancy should use acceptable birth control methods
Must not be pregnant
Subject, subject's parent, or legal representative must be capable of giving writteninformed consent/assent
Exclusion
Exclusion Criteria:
Immunocompromised at screening
Chronic or acute systemic or superficial infection requiring treatment with systemicantibacterials or antifungals within one week prior to baseline visit
Significant dermatological or inflammatory condition other than AD that, in theInvestigator's opinion, would make it difficult to interpret data or assessmentsduring the study
Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≥2.0x the upperlimit of normal (ULN).
Screening total bilirubin > 1.5x ULN
Current or chronic history of liver disease
Current or history of cancer within 5 years except for adequately treated cutaneousbasal cell carcinoma, squamous cell carcinoma or carcinoma in situ of the cervix
Subjects who would not be considered suitable for topical therapy
Use of any prohibited medication or procedure within the indicated period before thebaseline visit including other investigational product within 30 days or 5half-lives of the investigational product (whichever is longer)
History of or ongoing serious illness or medical, physical, or psychiatriccondition(s) that, in the Investigator's opinion, may interfere with the subject'sparticipation in the study, interpretation of results, or ability to understand andgive informed consent.
Pregnant or lactating females
History of sensitivity to the study medications, or components thereof or a historyof drug or other allergy that, in the opinion of the -Investigator or MedicalMonitor, contraindicates their participation
Previous known participation in a clinical study with tapinarof (previously known asGSK2894512 and WBI-1001)
Study Design
Study Description
Connect with a study center
Dermavant Investigative Site
Surrey, British Columbia V3R 6A7
CanadaSite Not Available
Dermavant Investigative Site
Barrie, Ontario L4M 7G1
CanadaSite Not Available
Dermavant Investigative Site
Markham, Ontario L3P 1X3
CanadaSite Not Available
Dermavant Investigative Site
Waterloo, Ontario N2J 1C4
CanadaSite Not Available
Dermavant Investigative Site
Windsor, Ontario N8W 1E6
CanadaSite Not Available
Dermavant Investigative Site
Birmingham, Alabama 35244
United StatesSite Not Available
Dermavant Investigative Site
Scottsdale, Arizona 85255
United StatesSite Not Available
Dermavant Investigative Site
Fort Smith, Arkansas 72916
United StatesSite Not Available
Dermavant Investigative Site
Cerritos, California 90702
United StatesSite Not Available
Dermavant Investigative Site
Huntington Beach, California 92647
United StatesSite Not Available
Dermavant Investigative Site
Lancaster, California 93534
United StatesSite Not Available
Dermavant Investigative Site
Long Beach, California 90806
United StatesSite Not Available
Dermavant Investigative Site
Los Angeles, California 90045
United StatesSite Not Available
Dermavant Investigative Site
San Diego, California 92123
United StatesSite Not Available
Dermavant Investigative Site
San Francisco, California 94115
United StatesSite Not Available
Dermavant Investigative Site
Santa Ana, California 92701
United StatesSite Not Available
Dermavant Investigative Site
Santa Monica, California 90404
United StatesSite Not Available
Dermavant Investigative Site
Boca Raton, Florida 33428
United StatesSite Not Available
Dermavant Investigative Site
Delray Beach, Florida 33484
United StatesSite Not Available
Dermavant Investigative Site
Jacksonville, Florida 32256
United StatesSite Not Available
Dermavant Investigative Site
Miami, Florida 33165
United StatesSite Not Available
Dermavant Investigative Site
Miami Lakes, Florida 33014
United StatesSite Not Available
Dermavant Investigative Site
Tampa, Florida 33607
United StatesSite Not Available
Dermavant Investigative Site
Snellville, Georgia 30078
United StatesSite Not Available
Dermavant Investigative Site
Evansville, Indiana 47715
United StatesSite Not Available
Dermavant Investigative Site
Overland Park, Kansas 66210
United StatesSite Not Available
Dermavant Investigative Site
Lexington, Kentucky 40517
United StatesSite Not Available
Dermavant Investigative Site
Louisville, Kentucky 40241
United StatesSite Not Available
Dermavant Investigative Site
Baton Rouge, Louisiana 70809
United StatesSite Not Available
Dermavant Investigative Site
New Orleans, Louisiana 70115
United StatesSite Not Available
Dermavant Investigative Site
Rockville, Maryland 20850
United StatesSite Not Available
Dermavant Investigative Site
Detroit, Michigan 48202
United StatesSite Not Available
Dermavant Investigative Site
Lincoln, Nebraska 68516
United StatesSite Not Available
Dermavant Investigative Site
Omaha, Nebraska 68114
United StatesSite Not Available
Dermavant Investigative Site
Las Vegas, Nevada 89148
United StatesSite Not Available
Dermavant Investigative Site
East Windsor, New Jersey 08520
United StatesSite Not Available
Dermanvant Investigative Site
Brooklyn, New York 11203
United StatesSite Not Available
Dermavant Investigative Site
Watertown, New York 13601
United StatesSite Not Available
Dermavant Investigative Site
Charlotte, North Carolina 28277
United StatesSite Not Available
Dermavant Investigative Site
Dayton, Ohio 45414
United StatesSite Not Available
Dermavant Investigative Site
Mason, Ohio 45040
United StatesSite Not Available
Dermavant Investigative Site
Mayfield Heights, Ohio 44124
United StatesSite Not Available
Dermavant Investigative Site
Tulsa, Oklahoma 74114
United StatesSite Not Available
Dermavant Investigative Site
Medford, Oregon 97504
United StatesSite Not Available
Dermavant Investigative Site
Portland, Oregon 97239
United StatesSite Not Available
Dermavant Investigative Site
East Greenwich, Rhode Island 02818
United StatesSite Not Available
Dermavant Clinical Site
Warwick, Rhode Island 02886
United StatesSite Not Available
Dermavant Investigative Site
Anderson, South Carolina 29621
United StatesSite Not Available
Dermavant Investigative Site
North Charleston, South Carolina 29420
United StatesSite Not Available
Dermavant Investigative Site
Spartanburg, South Carolina 29303
United StatesSite Not Available
Dermavant Investigative Site
Memphis, Tennessee 38119
United StatesSite Not Available
Dermavant Investigative Site
Bellaire, Texas 77401
United StatesSite Not Available
Dermavant Investigative Site
Dripping Springs, Texas 78620
United StatesSite Not Available
Dermavant Investigative Site
Grapevine, Texas 76051
United StatesSite Not Available
Dermavant Investigative Site
Houston, Texas 77004
United StatesSite Not Available
Dermavant Investigative Site
San Antonio, Texas 78213
United StatesSite Not Available
Dermavant Investigative Site
Webster, Texas 77598
United StatesSite Not Available
Dermavant Investigative Site
Spokane, Washington 99202
United StatesSite Not Available
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