Study of BOTOX Injections in Prevention of Migraine in Adult Participants With Episodic Migraine

Inclusion Criteria:

• History of migraine headache disorder meeting International Classification ofHeadache Disorders (ICHD)-3 diagnostic criteria for migraine with aura or migrainewithout aura for >= 12 months.

• Onset of migraine before 50 years of age.

• History of 6 to 14 migraine days/month in each of the 3 months prior to Visit 1.

• Six to 14 migraine/probable migraine days during the 4-week screening/baselinephase.

• Less than 15 headache days/month in each of the 3 months prior to Visit 1 and duringthe 4-week screening/baseline phase.

Exclusion Criteria:

• Current diagnosis of chronic migraine according to ICHD-3.

• History or current diagnosis of migraine with brainstem aura, retinal migraine,complications of migraine, chronic tension-type headache, trigeminal autonomiccephalalgias, hypnic headache, hemicrania continua, or new daily persistentheadache.

• History of headache attributed to another disorder (e.g., cervical dystonia,craniotomy, head/neck trauma) with exception that medication overuse headache perICHD-3 criteria is allowed.

• History of inadequate response to > 4 prophylactic treatment for migraine, 2 ofwhich have different mechanisms of action.

• Female who is pregnant, breastfeeding, or considering becoming pregnant during thestudy or within 90 days after the last dose of study drug.