ECMOsorb Trial - Impact of a VA-ECMO in Combination with CytoSorb in Critically Ill Patients with Cardiogenic Shock

Inclusion Criteria:

• Cardiogenic shock of any cause and indication for VA-ECMO

• Age between 18 and 80

• Signed informed consent

Exclusion Criteria:

• Current participation in another interventional trial

• Pregnancy

• Current immunosuppressive or immunomodulatory therapy

• Contraindications to VA-ECMO implantation.

• Patients with pre - existing sepsis (raised CPR, positive PCT, leukozytosis, fever,positive blood cultures).

• Shock duration> 12 h before evaluation.

• Severe PVD (peripheral vessel disease) making ECMO-implantation impossible.

• Aortic valve insufficiency / stenosis at least II °.

• Age > 80 years.

• CNS disease with fixed, dilated pupils (not drug-induced).

• Severe concomitant disease with limited life expectancy <6 months.

• CPR> 60min.

• Shock due to other reasons

• HIT positive (Heparin induced thrombocytopenia)

• Very low platelet counts (< 20,000/µl)

• Body weight less than 45 kg