Whole Egg Intake and Choline Concentration in the Aging Brain

Last updated: August 13, 2024
Sponsor: University of Kansas Medical Center
Overall Status: Completed

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT05021211
STUDY00146588
  • Ages 60-85
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

By doing this study, researchers hope to learn to see if there is relationship between whole egg consumption and brain choline status. Additionally, researchers also plan to see if there is a relationship between brain choline status and cognition.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Aged between 60 - 85 years of age

  • Good general health with no concomitant diseases

  • Cognitively normal as defined as Mini-mental state examination (MMSE) score ≥ 25

  • BMI range: 20 - 40 kg/m2

Exclusion

Exclusion Criteria:

  • Presence of central neurological disease (e.g., brain tumor, stroke, epilepsy, motorneuron disease, multiple sclerosis, Alzheimer's, Parkinson's)

  • Prior major head trauma with loss of consciousness

  • Presence of active unstable and life-threatening illness (e.g., cancer)

  • Presence of major psychiatric disorder within the past 3 years including depression,anxiety, and alcohol (over 3 drinks per day or total of 18 per week) or drug abuse (DSM-IV criteria; Geriatric Depression Score > 6)

  • Presence of diabetes mellitus or use of anti-diabetic agents

  • Use of psychoactive and investigational medications

  • Use of hormone replacement therapy

  • Tobacco smokers

  • Subjects with MRI contraindications

Study Design

Total Participants: 60
Study Start date:
June 01, 2021
Estimated Completion Date:
May 01, 2024

Study Description

Participants will come to the research center for 2 different visits. Visit 1 will include anthropometric measurements, surveys, and a cognitive test. Approximately 7-10 days after visit 1, participants will come back to the research center for visit 2. At visit 2, participants will return surveys and a MRI scan will be performed to measure brain choline status. Potential participants need to be located within the Kansas City metro area.

Connect with a study center

  • University of Kansas Medical Center

    Kansas City, Kansas 66160
    United States

    Site Not Available

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