The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) Study

Phase

N/A

Condition

Memory Loss

Mental Disability

Dementia

Treatment

N/A

Clinical Study ID

NCT05007353

SINGER 2021

Ages 60-77
All Genders
Accepts Healthy Volunteers

Study Summary

A study in Finland found that a multidomain intervention of physical activity, nutritional guidance, cognitive training, social activities and management of vascular risk factors slowed cognitive decline in healthy older adults at increased risk of cognitive decline. A 6-month pilot study was initiated in Singapore, which demonstrated the cultural feasibility and practicality of the FINGER interventions and a set of locally adapted interventions in an Asian population. The SINGER study is a 2-year randomized controlled trial that aims to test the efficacy and safety of these lifestyle changes, including diet and cardiovascular risk factor management, cognitive and physical exercises, in delaying cognitive decline in older adults at risk of dementia.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Age 60-77 years
Able to understand English/Chinese
Risk of dementia: Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) dementia risk score >6 indicating the presence of modifiable risk factorsModifiable lifestyle factors (fulfilling at least one of the following LIBRA index fordiet, cognitive activity, physical activity)
Cognitive performance at the mean level or slightly lower than expected for age (MoCA ≥18, ≤27)
No plans to travel outside of Singapore for an extended period of time over the courseof the study
Free of physical disabilities that preclude participation in the study
Willing to complete all study-related activities for 24 months
Willing to be randomized to either lifestyle intervention group

Exclusion

Exclusion Criteria:

malignant diseases
dementia
substantial cognitive decline (MoCA<18)
major depression
symptomatic cardiovascular disease
revascularisation within 1 year
severe loss of vision, hearing or communicative ability
other conditions inhibiting from safe engagement in the prescribed intervention andother conditions preventing cooperation, as judged by the study physician

Study Design

August 23, 2021

January 31, 2026

Study Description

Results from a population-based 2-year clinical trial, the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), demonstrated that a multidomain intervention of physical activity, nutritional guidance, cognitive training, social activities and management of vascular risk factors slowed cognitive decline in healthy older adults at increased risk of cognitive decline. Currently, no pharmacological treatment options that can rival these effects. Thus, there is an urgent need to test the generalizability, adaptability, and sustainability of these findings in Singaporean populations. A 6-month pilot study was initiated in Singapore, which demonstrated the cultural feasibility and practicality of the FINGER interventions and a set of locally adapted interventions in an Asian population. Hence, the next step was to conduct a larger scale SINGER trial to determine the efficacy of these interventions in Singapore. If the interventions are found to be effective and safe with high applicability and scalability, the study will provide important clinical and public health implications to a rapidly increasing ageing population.

Connect with a study center

National Neuroscience Institute @ Tan Tock Seng Campus (NNI @ TTSH campus)
Singapore, 308433
Singapore
Site Not Available
National University Hospital
Singapore, 117600
Singapore
Active - Recruiting
National University of Singapore, Yong Loo Lin School of Medicine
Singapore, 117600
Singapore
Active - Recruiting

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