In Vitro Drug Sensitivity Testing of Fresh Human Samples

Last updated: March 2, 2022
Sponsor: Hospices Civils de Lyon
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Allergy

Allergies & Asthma

White Cell Disorders

Treatment

N/A

Clinical Study ID

NCT05001386
69HCL21_0622
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Hematological malignancies gather several various pathologies included myeloproliferative disorders (as acute myeloid leukemia (AML) or chronic myeloid leukemia (CML)) and lymphoproliferative disorders (as chronic lymphoid leukemia (CLL), non-Hodgkin lymphoma (NHL) and multiple myeloma (MM)) .

Over the last decade, the treatments have evolved significantly but the overall survival remains limited, especially for the AML and MM patients. There's an ongoing imperative to continue in-vitro and in-vivo studies to better evaluate the anti-cancer drugs sensitivity and therefore improving the response to treatments and open new fields of application. The healthy control group will be contributing to produce some pertinent and significant data for the results of the index cases group.

The investigators aim to analyze 10 differents drugs, common use in chemotherapy or immunotherapy and evaluate by 2 ways the sensitivity: first, Flow cytometry (cells apoptosis by Annexine V and propidium iodide) on fresh samples and in a second time, monitoring of the blasts in the mouse's blood after injection.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Index cases: patients with myeloproliferative or lymphoproliferative disorders.
  • Controls: patients without hematological disease, without chemotherapy ((≤ 5 years.)and without immunosuppressive treatment at the study time.
  • Age ≥ 18 y.o for all the patients

Exclusion

Exclusion Criteria:

  • Age < 18 y.o
  • Pregnant or breastfeeding woman
  • Patients deprived of their liberty by judicial or administrative decision.

Study Design

Total Participants: 800
Study Start date:
March 01, 2022
Estimated Completion Date:
March 31, 2025

Connect with a study center

  • Centre Hospitalier Lyon Sud -Service d'Hématologie

    Pierre-Bénite, 69495
    France

    Site Not Available

  • Centre Hospitalier Lyon Sud -Service de médecine du vieillissement

    Pierre-Bénite, 69495
    France

    Site Not Available

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