Improving Cognition and Behavior in Pediatric Cancer Survivors Using a Novel Mindful Attention Training

Last updated: July 31, 2025
Sponsor: University of California, San Francisco
Overall Status: Trial Not Available

Phase

N/A

Condition

Retinoblastoma

Neuroblastoma

Treatment

Adaptive Attention Training

Questionnaires

Clinical Study ID

NCT05000905
210822
NCI-2022-07364
  • Ages 7-17
  • All Genders

Study Summary

This pilot study will evaluate the cognitive and behavioral outcomes of using a novel, adaptive attention training in pediatric cancer survivors.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Age 7-17 at the time of enrollment.

  2. Able to understand study procedures and to comply with them for the entire length ofthe study.

  3. Ability of individual and legal guardian/representative to understand a writteninformed consent document, and the willingness to sign it.

  4. Normal or corrected-normal vision and hearing.

  5. English language fluency (minor participant and parent/guardian).

  6. Received radiation therapy to the brain or neck between age 7-17.

  7. Patients not on current cancer-related treatment (except supportive care) or thoseon other current treatments that would not hinder study participation. Patientscurrently on cancer-related treatments will be discussed with the study team (co-PIMueller).

Exclusion

Exclusion Criteria:

  1. Contraindication to any study-related procedure or assessment.

  2. Motor/perceptual difficulties that prevent computer or tablet use.

  3. Current cancer-related treatments that would impact the ability to participate inthe study (e.g., current inpatient chemotherapy or intrathecal chemotherapy).Patients on other current treatments will be discussed with the study team (co-PI,Dr. Mueller)

Study Design

Treatment Group(s): 2
Primary Treatment: Adaptive Attention Training
Phase:
Study Start date:
March 20, 2023
Estimated Completion Date:
May 31, 2025

Study Description

Pediatric cancer survivors (PCS) often experience attentional difficulties that have downstream effects on their quality of life, academic achievement, and future occupational attainment. As such, the primary goal of this project is to examine the outcomes of a novel, mindful attention training in this population and assess the feasibility of recruitment, retention, and adherence. Specifically, PCS will be randomly assigned to one of two adaptive attention training groups ('Engage') and complete tasks on the device for up to 8 weeks. Participants will also complete pre- and post-training assessments of cognition and behavior.

An additional cohort of no-contact participants will be asked to complete the assessments at baseline and end of study only to assess the feasibility and reliability of the assessment measures. This cohort will be enrolled separately and not randomized.

The investigators hypothesize that completion of 'Engage' training for the randomized cohorts will result in enhanced attentional control beyond the active comparator group that extends to other aspects of cognition in PCS.