A Study of LP-168 in Participants with Relapse or Refractory B-Cell Lymphoma

Key Inclusion Criteria:

• Per 2017 revised WHO lymphoma classification criteria, subject must have either:

Diagnosed with relapsed or refractory DLBCL or FL and require treatment in the opinion of the Investigator and have received 2 lines SOC.

Diagnosed with relapsed or refractory non-Hodgkin's lymphoma associated with B-cell proliferation (such as CLL\ SLL \ MCL \ MZL \ WM, etc.) in need of treatment in the opinion of the Investigator and have received 1 line SOC.

• Adequate hematologic function.

• Adequate hepatic and renal function.

• Ability to receive study drug therapy orally and willing to receive examinations.

• Willingness of men and women of reproductive potential (defined as followingmenarche and not postmenopausal [and 2 years of non-therapy-induced amenorrhea] orsurgically sterile) to observe conventional and effective birth control.

Key Exclusion Criteria:

• According to the 2017 revised WHO Lymphoma Classification Criteria, patientsdiagnosed with the following diseases: Burkitt lymphoma or Burkitt-like lymphoma,lymphoblastic lymphoma/leukemia, and post-transplant lymphoproliferativedisease(PTLD).

• Prior malignancy (other than the disease under study) within the past 3 years,except for curatively treated basal or squamous cell skin cancer, carcinoma in situof the cervix or breast cancer.

• Subjects who have received the following treatments within 4 weeks or 5 half-livesbefore the first dose of LP-168:

Antitumor therapies including myelosuppressive chemotherapy, targeted therapy, biological therapy and/or immunotherapy; Any investigational treatment; Patients who have undergone major surgery, severe trauma or radiotherapy.

• Subjects who have received the following treatments within 2 weeks before the firstdose of LP-168:

Steroids or traditional herbal medicine for antitumor purposes; Strong and moderate CYP3A inhibitors and inducers; All drugs that may cause QTc interval prolongation or torsional tachycardia.

• Disease states where clinical manifestations may be difficult to control, includingHIV, HBV, HCV, syphilis positive or active bacterial and fungal infections; Diseaseaffects the central nervous system with obvious symptoms; Autoimmune hemolyticanemia or Idiopathic thrombocytopenic purpura. Any gastrointestinal conditions thatmay severely affect the study drug absorption or pharmacokinetic parameters.

• Subjects who cannot tolerate urine collection, venipuncture, lymph node biopsy, andbone marrow aspiration.