Effect of Tramadol on Postoperative Sore Throat After General Anesthesia

Last updated: May 10, 2024
Sponsor: Affiliated Cancer Hospital of Shantou University Medical College
Overall Status: Active - Recruiting

Phase

4

Condition

Pharyngitis

Treatment

Normal Saline

Tramadol hydrochloride

Clinical Study ID

NCT04991493
QPOST
  • Ages 18-65
  • Female

Study Summary

Post operative sore throat after general anesthesia with endotracheal intubation is a common problem causing dissatisfaction and discomfort to the patients. The investigators want to study the effect of tramadol on postoperative sore throat in general anesthesia with endotracheal intubation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Female with American Society of Anesthesiologists (ASA) physical status I-II;Elective thyroidectomy(non-endoscopic) with endotracheal intubation; The patientsigned the consent form.

Exclusion

Exclusion Criteria:

  • History of thyroid surgery A history of preoperative sore throat; Pregnancy;Retrosternal goiter; Thyroid tumor invading trachea need trachea reconstruction;Potentially difficult airway; Clinical diagnosis of chronic sore throat; Clinicaldiagnosis of psychosis; Tracheotomy after operation； Transfer to intensive care unitafter operation； Contraindications to tramadol； Body mass index (BMI) > 30kg/m^2.

Study Design

Total Participants: 168
Treatment Group(s): 2
Primary Treatment: Normal Saline
Phase: 4
Study Start date:
September 10, 2021
Estimated Completion Date:
July 31, 2024

Study Description

Design: A prospective, randomized, controlled study. Setting: Single-center university hospital. Participants: The study included 168 patients undergoing thyroid surgery under general anesthesia with endotracheal intubation.

Interventions: The patients were allocated randomly into the following 3 groups: the control group: patients will be injected intravenously 5ml of normal saline 15 minutes before anesthesia and another 5ml of normal saline was injected intravenously when the incision was washed and sutured；the pre-tramadol group: patients will be injected intravenously 5ml of tramadol (1mg / kg) 15 minutes before anesthesia and 5ml of normal saline was injected intravenously when the incision was washed and sutured. the post-tramadol group: patients will be injected intravenously 5ml of normal saline 15 minutes before anesthesia and 5ml of tramadol (1mg / kg) was injected intravenously when the incision was washed and sutured. Postoperatively, all patients will receive standard treatment.

Connect with a study center

  • Affiliated Cancer Hospital of Shantou University Medical College Medical

    Shantou, Guangdong 515041
    China

    Active - Recruiting

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