Safety and Efficacy of Efavaleukin Alfa in Participants With Moderately to Severely Active Ulcerative Colitis

Last updated: November 21, 2024
Sponsor: Amgen
Overall Status: Terminated

Phase

2

Condition

Ulcerative Colitis

Bowel Dysfunction

Ulcers

Treatment

Efavaleukin alfa

Placebo

Clinical Study ID

NCT04987307
20170104
2021-002537-41
  • Ages 18-80
  • All Genders

Study Summary

The main purpose of this study is to evaluate the effect of efavaleukin alfa on induction of clinical remission in participants with moderately to severely active ulcerative colitis (UC).

Participants will be randomized to receive 1 of 3 efavaleukin alfa doses or placebo during a 12-week induction period. Participants who complete the 12-week induction period will have the option to enter an exploratory long-term treatment period for up to 40 weeks (total of up to 52 weeks of treatment) if, in the opinion of the investigator, they may benefit from continued treatment. During the long-term period, participants randomized to efavaleukin alfa will remain on the same efavaleukin alfa blinded dose; participants randomized to placebo who achieved clinical response at week 12 will remain on placebo; and placebo non-responders (ie, participants randomized to placebo who did not achieve clinical response at week 12) will receive efavaleukin alfa in a blinded manner during continued treatment. All participants will complete a safety follow-up visit 6 weeks after their last dose of investigational product.

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  • Participant has provided informed consent prior to initiation of any study specificactivities or procedures.

  • Men and women aged ≥ 18 to < 80 years at screening visit (≥ 19 to < 80 in SouthKorea).

  • Diagnosis of UC established ≥ 3 months prior to enrollment by clinical andendoscopic evidence and corroborated by a histopathology report. If a histopathologyreport is not available at screening, then additional biopsies may be taken duringthe screening period for local histopathology analysis to corroborate.

  • Moderately to severely active UC as defined by a modified Mayo score of 5 to 9, witha centrally read endoscopy subscore ≥ 2.

  • Has documentation of:

  • A surveillance colonoscopy (performed according to local standard) within 12months of day 1 visit for participants with pancolitis of > 8 years duration,or participants with left-sided colitis of > 12 years duration, or participantswith primary sclerosing cholangitis.

  • At the discretion of the investigator, a colonoscopy (instead of arectosigmoidoscopy) may be performed as the screening endoscopy for this study.

  • For all other participants, up-to-date colorectal cancer surveillance (performed according to local standard). Participants who do not have acolonoscopy report available in source documentation will have a colonoscopyinstead of rectosigmoidoscopy performed as the screening endoscopy for thestudy.

  • Participants must have demonstrated inadequate response, loss of response, orintolerance to at least 1 conventional therapy, biologic therapy, or targeted smallmolecule therapy (ie, Janus kinase [JAK]-inhibitor or or S1P modulators), asfollows:

  1. Conventional therapy failed participants:
  • Corticosteroids (corticosteroid-refractory colitis, defined as signsand/or symptoms of active UC despite oral prednisone [or equivalent] atdoses of at least 30 mg/day for a minimum of 2 weeks; orcorticosteroid-dependent colitis, defined as: an inability to reducecorticosteroids below the equivalent of prednisone 10 mg/day within 3months of starting corticosteroids without a return of signs and/orsymptoms of active UC; or a relapse within 3 months of completing a courseof corticosteroids).
  • History of intolerance of corticosteroids (including, but not limited to,Cushing's syndrome, osteopenia/ osteoporosis, hyperglycemia, orneuropsychiatric side-effects, including insomnia, associated withcorticosteroid treatment).
  • Immunomodulators: signs and/or symptoms of persistently active diseasedespite at least 3 months treatment with one of the following at locallyapproved doses: oral azathioprine (eg, ≥ 1.5 mg/kg/day) or 6-mercaptopurine (eg, ≥ 0.75 mg/kg/day), or oral azathioprine or 6-mercatopurine within a therapeutic range as judged by thioguaninemetabolite testing, or a combination of a thiopurine and allopurinolwithin a therapeutic range as judged by thioguanine metabolite testing.
  • History of intolerance to at least 1 immunomodulator (including but notlimited to nausea/vomiting, abdominal pain, pancreatitis, liver functiontest abnormalities, and lymphopenia) and have neither failed nordemonstrated an intolerance to a biological medication (anti-tumornecrosis factor [TNF] antibody, anti-integrin antibody, or interleukin [IL]-12/23 antagonists) that is indicated for the treatment of UC.
  1. Biologic or targeted small molecule therapy failed participants: those whodemonstrated inadequate response or loss of response or intolerance to biologictherapy for UC (eg, anti-TNF antibodies or IL-12/23 antagonists, anti-integrinantibodies) or targeted small molecules (eg, JAK inhibitors or S1P modulators).The therapy used to qualify the participant for entry into this category mustbe approved for the treatment of UC in the country of use, at the time of use.Participants must fulfil one of the following criteria:
  • Inadequate response: signs and symptoms of persistently active diseasedespite induction treatment at the approved induction dosing that wasindicated in the product label at the time of use.

  • Loss of response: recurrence of signs and symptoms of active diseaseduring approved maintenance dosing following prior clinical benefit (discontinuation despite clinical benefit does not quality as havingfailed or being intolerant to UC biological therapy, JAK inhibitor, or S1Pmodulators).

  • Intolerance: history of intolerance to infliximab, adalimumab, golimumab,vedolizumab, ustekinumab, tofacitinib or other approved biologicals, JAKinhibitors or S1P modulators (including but not limited toinfusion-related event, demyelination, congestive heart failure, or anyother drug-related adverse event that led to a reduction in dose ordiscontinuation of the medication).

  • If receiving any of the following therapies, participants must have stable dosagefor the specified duration:

  • 5-aminosalicylates (ASAs), stable dosage for ≥ 2 weeks prior to screeningendoscopy.

  • Oral corticosteroids: prednisone ≤ 20 mg/day or its equivalent, stable dose for ≥ 2 weeks prior to screening endoscopy.

  • Budesonide: extended release tablets 9 mg/day [budensonide MMX], stable dosefor ≥ 2 weeks prior to screening endoscopy.

  • Beclomethasone dipropionate: gastro-resistant prolonged-release tablet 5mg/day, stable dose for >= 2 weeks prior to screening endoscopy.

  • Conventional immunomodulators: azathioprine, 6-mercaptopurine, methotrexate,stable dosage for ≥ 12 weeks prior to screening endoscopy.

Exclusion

Key Exclusion Criteria:

  • Diagnosis of Crohn's disease, inflammatory bowel disease unclassified (indeterminatecolitis), microscopic colitis, ischemic colitis, or clinical findings suggestive ofCrohn's disease.

  • Evidence of toxic megacolon, fulminant colitis, intra-abdominal abscess, orstricture/stenosis within the small bowel or colon.

  • Participant has had extensive surgery for UC (for example, subtotal colectomy), oris likely to require surgery for the treatment of UC during the study.

  • Currently receiving or had treatment within 12 months prior to screening with T celldepleting agents (eg, antithymocyte globulin, Campath).

  • Participant has received any of the following prescribed medication or therapywithin the specified time period:

  • Anti TNF antibodies (eg, infliximab, adalimumab, golimumab) < 8 weeks prior toscreening rectosigmoidoscopy.

  • Anti integrin antibodies (eg, vedolizumab) < 8 weeks prior to screeningrectosigmoidoscopy.

  • IL 12/23 antagonist (eg, ustekinumab) < 8 weeks prior to screeningrectosigmoidoscopy.

  • JAK inhibitors (eg, tofacitinib) < 4 weeks prior to screeningrectosigmoidoscopy.

  • Any other commercially approved biologic agent or targeted small molecule < 8weeks prior to screening rectosigmoidoscopy or < 5 half lives prior toscreening rectosigmoidoscopy, whichever is longer

  • Immunomodulatory medications, including oral cyclosporine, intravenouscyclosporine, tacrolimus, sirolimus, mycophenolate mofetil, thalidomide < 4weeks prior to screening rectosigmoidoscopy.

  • Any investigational biologic therapy within 8 weeks prior to screeningrectosigmoidoscopy or < 5 half-lives prior to screening rectosigmoidoscopy,whichever is longer.

  • Has used apheresis (eg, Adacolumnâ apheresis) < 2 weeks prior to screeningrectosigmoidoscopy.

Study Design

Total Participants: 224
Treatment Group(s): 2
Primary Treatment: Efavaleukin alfa
Phase: 2
Study Start date:
January 31, 2022
Estimated Completion Date:
October 22, 2024

Connect with a study center

  • Centro de Investigaciones Medicas Mar del Plata

    Mar del Plata, Buenos Aires B7600DHK
    Argentina

    Site Not Available

  • Clinica Independencia

    Munro, Buenos Aires 1605
    Argentina

    Site Not Available

  • Cer Instituto Medico

    Quilmes, Buenos Aires B1878DVB
    Argentina

    Site Not Available

  • CardioAlem Investigaciones

    San Isidro, Buenos Aires B1642DSF
    Argentina

    Site Not Available

  • Hospital Privado Centro Medico de Cordoba SA

    Cordoba, Córdoba X5000IYH
    Argentina

    Site Not Available

  • Fundacion Estudios Clinicos

    Rosario, Santa Fe 2000
    Argentina

    Site Not Available

  • Medizinische Universitaet Innsbruck

    Innsbruck, 6020
    Austria

    Site Not Available

  • Landeskrankenhaus Salzburg

    Salzburg, 5020
    Austria

    Site Not Available

  • Universitaetsklinikum Allgemeines Krankenhaus Wien

    Wien, 1090
    Austria

    Site Not Available

  • Universitair Ziekenhuis Antwerpen

    Edegem, 2650
    Belgium

    Site Not Available

  • Universitair Ziekenhuis Leuven - Campus Gasthuisberg

    Leuven, 3000
    Belgium

    Site Not Available

  • Centre Hospitalier Universitaire de Liege - Sart Tilman

    Liège, 4000
    Belgium

    Site Not Available

  • Acibadem City Clinic University Multiprofile Hospital for Active Treatment Mladost EOOD

    Sofia, 1784
    Bulgaria

    Site Not Available

  • Diagnostic-Consultative Center Convex EOOD

    Sofia, 1680
    Bulgaria

    Site Not Available

  • Second Multiprofile Hospital for Active Treatment - Sofia EAD

    Sofia, 1202
    Bulgaria

    Site Not Available

  • South Edmonton Gastroenterology

    Edmonton, Alberta T6K 4B2
    Canada

    Site Not Available

  • London Health Sciences Centre, University Hospital

    London, Ontario N6A 5A5
    Canada

    Site Not Available

  • TIDHI Innovation Incorporated

    Toronto, Ontario M6A 3B4
    Canada

    Site Not Available

  • Hepato-Gastroenterologie HK sro

    Hradec Kralove, 500 12
    Czechia

    Site Not Available

  • Nemocnice Pardubickeho kraje as, Pardubicka nemocnice

    Pardubice, 532 03
    Czechia

    Site Not Available

  • Axon Clinical sro

    Praha, 150 00
    Czechia

    Site Not Available

  • Nemocnice Milosrdnych sester sv Karla Boromejskeho v Praze

    Praha, 118 00
    Czechia

    Site Not Available

  • Krajska zdravotni as - Masarykova nemocnice Usti nad Labem oz

    Usti nad Labem, 401 13
    Czechia

    Site Not Available

  • Aalborg Universitetshospital

    Aalborg, 9000
    Denmark

    Site Not Available

  • Herlev Hospital

    Herlev, 2730
    Denmark

    Site Not Available

  • Hvidovre Hospital

    Hvidovre, 2650
    Denmark

    Site Not Available

  • Bispebjerg Hospital

    Kobenhavn NV, 2400
    Denmark

    Site Not Available

  • Helsinki University Central Hospital

    Helsinki, 00290
    Finland

    Site Not Available

  • Centre Hospitalier Universitaire Amiens Picardie

    Amiens cedex 1, 80054
    France

    Site Not Available

  • Centre Hospitalier Universitaire de Montpellier - Hopital Saint Eloi

    Montpellier cedex 5, 34295
    France

    Site Not Available

  • Centres Medicaux Chirurgicaux Ambroise Pare Hartmann

    Neuilly sur seine, 92200
    France

    Site Not Available

  • Centre Hospitalier Universitaire Archet 2

    Nice cedex 3, 06202
    France

    Site Not Available

  • Centre Hospitalier Universitaire Nord de Saint Etienne - Hopital Nord

    Saint Priest en Jarez, 42270
    France

    Site Not Available

  • Centre Hospitalier Universitaire Nord de Saint Etienne - Hôpital Nord

    Saint Priest en Jarez, 42270
    France

    Active - Recruiting

  • Centre Hospitalier Universitaire de Nancy - Hôpital de Brabois

    Vandoeuvre les Nancy Cedex, 54511
    France

    Site Not Available

  • Gastro-Studien GbR Studienzentrum

    Berlin, 10825
    Germany

    Site Not Available

  • Universitaetsklinikum Essen

    Essen, 45147
    Germany

    Site Not Available

  • Universitaetsklinikum Frankfurt

    Frankfurt am Main, 60590
    Germany

    Site Not Available

  • Universitaetsklinikum Schleswig-Holstein

    Kiel, 24105
    Germany

    Site Not Available

  • Universitaetsklinikum Tuebingen

    Tuebingen, 72076
    Germany

    Site Not Available

  • Universitaetsklinikum Ulm

    Ulm, 89081
    Germany

    Site Not Available

  • University General Hospital of Alexandroupolis

    Alexandroupoli, 68100
    Greece

    Site Not Available

  • General Hospital Evangelismos

    Athens, 10676
    Greece

    Site Not Available

  • Laiko General Hospital of Athens

    Athens, 11527
    Greece

    Site Not Available

  • University Hospital Attikon

    Haidari, 12462
    Greece

    Site Not Available

  • University Hospital of Heraklion

    Heraklion, 71500
    Greece

    Site Not Available

  • Venizeleio General Hospital

    Heraklion, 71409
    Greece

    Site Not Available

  • University General Hospital of Ioannina

    Ioannina, 45500
    Greece

    Site Not Available

  • General University Hospital of Patras Panagia i Voithia

    Patras, 26504
    Greece

    Site Not Available

  • Bekes Megyei Kozponti Korhaz Dr Rethy Pal Tagkorhaz

    Bekescsaba, 5600
    Hungary

    Active - Recruiting

  • Bekes Varmegyei Kozponti Korhaz Dr Rethy Pal Tagkorhaz

    Bekescsaba, 5600
    Hungary

    Site Not Available

  • Clinexpert Kft

    Budapest, 1033
    Hungary

    Site Not Available

  • MIND Klinika Kft

    Budapest, 1024
    Hungary

    Site Not Available

  • Obudai Egeszsegugyi Centrum Kft

    Budapest, 1036
    Hungary

    Site Not Available

  • Szegedi Tudomanyegyetem Szent Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar

    Szeged, 6725
    Hungary

    Active - Recruiting

  • Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar

    Szeged, 6725
    Hungary

    Site Not Available

  • Clinfan Kft

    Szekszard, 7100
    Hungary

    Site Not Available

  • Komarom-Esztergom Varmegyei Szent Borbala Korhaz

    Tatabanya, 2800
    Hungary

    Site Not Available

  • Szent Borbala Korhaz

    Tatabanya, 2800
    Hungary

    Active - Recruiting

  • Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

    Brescia, 25123
    Italy

    Site Not Available

  • Azienda Ospedaliera Universitaria Mater Domini

    Catanzaro, 88100
    Italy

    Active - Recruiting

  • Azienda Ospedaliera Universitaria Renato Dulbecco

    Catanzaro, 88100
    Italy

    Site Not Available

  • Azienda Ospedaliero Universitaria Careggi

    Firenze, 50134
    Italy

    Site Not Available

  • Ospedale Policlinico San Martino IRCCS

    Genoa, 16132
    Italy

    Site Not Available

  • Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico

    Milano, 20122
    Italy

    Site Not Available

  • IRCCS Ospedale San Raffaele

    Milano, 20132
    Italy

    Site Not Available

  • Ospedale Sacro Cuore Don Calabria

    Negrar VR, 37024
    Italy

    Site Not Available

  • Ospedale Sandro Pertini

    Roma, 00157
    Italy

    Site Not Available

  • Tsujinaka Hospital Kashiwanoha

    Kashiwa-shi, Chiba 277-0871
    Japan

    Site Not Available

  • Toho University Sakura Medical Center

    Sakura-shi, Chiba 285-8741
    Japan

    Site Not Available

  • Kitakyushu Municipal Medical Center

    Kitakyushu-shi, Fukuoka 802-8561
    Japan

    Site Not Available

  • Gifu University Hospital

    Gifu-shi, Gifu 501-1194
    Japan

    Site Not Available

  • Matsunami General Hospital

    Hashima-gun, Gifu 501-6062
    Japan

    Site Not Available

  • Hakodate Central General Hospital

    Hakodate-shi, Hokkaido 040-8585
    Japan

    Site Not Available

  • Sapporo Tokushukai Hospital

    Sapporo-shi, Hokkaido 004-0041
    Japan

    Site Not Available

  • Aoyama Clinic GI Endoscopy and IBD Center

    Kobe-shi, Hyogo 650-0015
    Japan

    Site Not Available

  • Aoyama Clinic, Gastrointestinal Endoscopy and Inflammatory Bowel Disease Center

    Kobe-shi, Hyogo 650-0015
    Japan

    Active - Recruiting

  • Gokeikai Ofuna Chuo Hospital

    Kamakura-shi, Kanagawa 247-0056
    Japan

    Site Not Available

  • Takagi Clinic

    Sendai-shi, Miyagi 981-3213
    Japan

    Site Not Available

  • Miyazaki Prefectural Miyazaki Hospital

    Miyazaki-shi, Miyazaki 880-8510
    Japan

    Site Not Available

  • Nagasaki University Hospital

    Nagasaki-shi, Nagasaki 852-8501
    Japan

    Site Not Available

  • Nara Medical University Hospital

    Kashihara-shi, Nara 634-8522
    Japan

    Site Not Available

  • National Hospital Organization Okayama Medical Center

    Okayama-shi, Okayama 701-1192
    Japan

    Site Not Available

  • Osaka Metropolitan University Hospital

    Osaka-shi, Osaka 545-8586
    Japan

    Site Not Available

  • Tokyo Medical and Dental University Hospital

    Bunkyo-ku, Tokyo 113-8519
    Japan

    Site Not Available

  • Kitasato University Kitasato Institute Hospital

    Minato-ku, Tokyo 108-8642
    Japan

    Site Not Available

  • Kyorin University Hospital

    Mitaka-shi, Tokyo 181-8611
    Japan

    Site Not Available

  • Ome Medical Center

    Ome-shi, Tokyo 198-0042
    Japan

    Site Not Available

  • Ome Municipal General Hospital

    Ome-shi, Tokyo 198-0042
    Japan

    Active - Recruiting

  • Hiratsuka Gastroenterological Hospital

    Toshima-ku, Tokyo 171-0021
    Japan

    Active - Recruiting

  • Medical Corporation ENEXT Ikebukuro West Gate Hospital

    Toshima-ku, Tokyo 171-0021
    Japan

    Site Not Available

  • Yamanashi Prefectural Central Hospital

    Kofu-shi, Yamanashi 400-8506
    Japan

    Site Not Available

  • Inje University Haeundae Paik Hospital

    Busan, 48108
    Korea, Republic of

    Site Not Available

  • Yeungnam University Hospital

    Daegu, 42415
    Korea, Republic of

    Active - Recruiting

  • Yeungnam University Medical Center

    Daegu, 42415
    Korea, Republic of

    Site Not Available

  • Samsung Medical Center

    Seoul, 06351
    Korea, Republic of

    Site Not Available

  • The Catholic University of Korea Seoul St Marys Hospital

    Seoul, 06591
    Korea, Republic of

    Site Not Available

  • Wonju Severance Christian Hospital

    Wonju-si, Gangwon-do, 26426
    Korea, Republic of

    Site Not Available

  • Digestive Diseases Centre GASTRO

    Riga, 1079
    Latvia

    Active - Recruiting

  • Gastro Centrs

    Riga, 1079
    Latvia

    Site Not Available

  • Pauls Stradins Clinical University Hospital

    Riga, 1002
    Latvia

    Site Not Available

  • Clinicos Asociados BOCM SC

    Ciudad de Mexico, Distrito Federal 03300
    Mexico

    Site Not Available

  • Clinica de Investigacion en Reumatologia y Obesidad SC

    Guadalajra, Jalisco 44650
    Mexico

    Site Not Available

  • Investigacion Biomedica para el Desarrollo de Farmacos SA de CV

    Zapopan, Jalisco 45070
    Mexico

    Site Not Available

  • CRI Centro Regiomontano de Investigacion SC

    Monterrey, Nuevo León 64060
    Mexico

    Site Not Available

  • Hospital San Jose Tec Salud Fundacion Santos y de la Garza Evia IBP

    Monterrey, Nuevo León 64710
    Mexico

    Site Not Available

  • Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada SC

    Culiacan, Sinaloa 80230
    Mexico

    Site Not Available

  • Leids Universitair Medisch Centrum

    Leiden, 2333 ZA
    Netherlands

    Site Not Available

  • Elisabeth TweeSteden Ziekenhuis

    Tilburg, 5022 GC
    Netherlands

    Site Not Available

  • Elisabeth-TweeSteden Ziekenhuis

    Tilburg, 5022 GC
    Netherlands

    Active - Recruiting

  • Universitair Medisch Centrum Utrecht

    Utrecht, 3584 CX
    Netherlands

    Site Not Available

  • NZOZ Twoje Zdrowie EL Spzoo

    Elblag, 82-300
    Poland

    Site Not Available

  • Centrum Medyczne Med-Gastr Sp zoo

    Lodz, 91-034
    Poland

    Site Not Available

  • Med-Gastr Sp zoo Sp k

    Lodz, 91-034
    Poland

    Active - Recruiting

  • Centrum Badawcze Panaceum Agnieszka Brzezicka Magdalena Lenkiewicz Spzoo

    Malbork, 82-200
    Poland

    Site Not Available

  • Oleg Tyszkiwski Centrum Gastrologiczne Gorczyn Oleg Tyszkiwski

    Poznan, 60-123
    Poland

    Site Not Available

  • Centrum Medyczne Pratia Poznan

    Skorzewo, 60-185
    Poland

    Site Not Available

  • BodyClinic spolka z ograniczona odpowiedzialnoscia

    Warszawa, 03-712
    Poland

    Site Not Available

  • EuroMediCare Przychodnia Specjalistyczna we Wroclawiu

    Wroclaw, 54-144
    Poland

    Site Not Available

  • Centrum Medyczne Melita Medical

    Wroclaw-Krzyki, 50-449
    Poland

    Site Not Available

  • Institutul Clinic Fundeni

    Bucharest, 022328
    Romania

    Site Not Available

  • Clinica Medicum

    Bucuresti, 012015
    Romania

    Site Not Available

  • Memorial Healthcare International SRL

    Bucuresti, 013812
    Romania

    Site Not Available

  • Spitalul Clinic Colentina

    Bucuresti, 020125
    Romania

    Site Not Available

  • Spitalul Universitar de Urgenta Militar Central Dr Carol Davila

    Bucuresti, 010825
    Romania

    Site Not Available

  • Spitalul Universitar de Urgenta Militar Central Dr. Carol Davila

    Bucuresti, 010825
    Romania

    Active - Recruiting

  • Spitalul de Oncologie Monza SRL

    Bucuresti, 013812
    Romania

    Active - Recruiting

  • Spitalul Clinic Pelican

    Oradea, 410445
    Romania

    Site Not Available

  • Fakultna Nemocnica s poliklinikou FD Roosevelta Banska Bystrica

    Banska Bystrica, 975 17
    Slovakia

    Site Not Available

  • Endomed, sro

    Kosice, 040 13
    Slovakia

    Site Not Available

  • Gastro I, sro

    Presov, 080 01
    Slovakia

    Site Not Available

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, Cataluña 08041
    Spain

    Site Not Available

  • Hospital General Universitario Gregorio Marañon

    Madrid, 28028
    Spain

    Site Not Available

  • Hospital Universitario La Paz

    Madrid, 28046
    Spain

    Site Not Available

  • Hospital Universitario de La Princesa

    Madrid, 28006
    Spain

    Site Not Available

  • Inselspital Bern

    Bern, 3010
    Switzerland

    Site Not Available

  • Intesto BE

    Bern, 3012
    Switzerland

    Site Not Available

  • Kantonsspital St Gallen

    Sankt Gallen, 9007
    Switzerland

    Site Not Available

  • Kantonsspital St Gallen

    St. Gallen, 9007
    Switzerland

    Site Not Available

  • Universitaetsspital Zuerich

    Zuerich, 8091
    Switzerland

    Site Not Available

  • Universitaetsspital Zuerich

    Zurich, 8091
    Switzerland

    Site Not Available

  • China Medical University Hospital

    Taichung, 40447
    Taiwan

    Site Not Available

  • National Taiwan University Hospital

    Taipei, 10002
    Taiwan

    Site Not Available

  • Taipei Veterans General Hospital

    Taipei, 11217
    Taiwan

    Site Not Available

  • Ankara Bilkent Sehir Hastanesi

    Ankara, 06800
    Turkey

    Site Not Available

  • Antalya Egitim ve Arastirma Hastanesi

    Antalya, 07100
    Turkey

    Site Not Available

  • Uludag Universitesi Tip Fakultesi

    Bursa, 16059
    Turkey

    Active - Recruiting

  • Uludag Universitesi Tip Fakultesi Hastanesi

    Bursa, 16059
    Turkey

    Site Not Available

  • Gaziantep Universitesi Tip Fakultesi

    Gaziantep, 27310
    Turkey

    Active - Recruiting

  • Gaziantep Universitesi Tip Fakultesi Hastanesi

    Gaziantep, 27310
    Turkey

    Site Not Available

  • Istanbul Universitesi Istanbul Tip Fakultesi

    Istanbul, 34093
    Turkey

    Active - Recruiting

  • Istanbul Universitesi Istanbul Tip Fakultesi Hastanesi

    Istanbul, 34093
    Turkey

    Site Not Available

  • Dokuz Eylul Universitesi Tip Fakultesi

    Izmir, 35330
    Turkey

    Active - Recruiting

  • Dokuz Eylul Universitesi Tip Fakultesi Hastanesi

    Izmir, 35330
    Turkey

    Site Not Available

  • Ege Universitesi Tip Fakultesi

    Izmir, 35100
    Turkey

    Active - Recruiting

  • Ege Universitesi Tip Fakultesi Hastanesi

    Izmir, 35100
    Turkey

    Site Not Available

  • Kocaeli Universitesi Tip Fakultesi

    Kocaeli, 41001
    Turkey

    Active - Recruiting

  • Kocaeli Universitesi Tip Fakultesi Hastanesi

    Kocaeli, 41001
    Turkey

    Site Not Available

  • Mersin Universitesi Tip Fakultesi

    Mersin, 33343
    Turkey

    Active - Recruiting

  • Mersin Universitesi Tip Fakultesi Hastanesi

    Mersin, 33343
    Turkey

    Site Not Available

  • Digestive Health Specialists of the Southeast

    Dothan, Alabama 36305
    United States

    Site Not Available

  • Birmingham Digestive Health Research, LLC

    Homewood, Alabama 35209
    United States

    Site Not Available

  • Arizona Health Research

    Mesa, Arizona 85206
    United States

    Site Not Available

  • Arizona Arthritis and Rheumatology Research, PLLC

    Phoenix, Arizona 85037
    United States

    Site Not Available

  • Southern California Research Center

    Coronado, California 92118
    United States

    Site Not Available

  • United Medical Doctors

    Los Alamitos, California 90720
    United States

    Site Not Available

  • Biopharma Informatic Inc

    Los Angeles, California 90035
    United States

    Active - Recruiting

  • Biopharma Informatic Incorporated

    Los Angeles, California 90035
    United States

    Site Not Available

  • Gastrointestinal Biosciences Clinical Trials Limited Liability Company

    Los Angeles, California 90067
    United States

    Site Not Available

  • University of California Irvine

    Orange, California 92868
    United States

    Site Not Available

  • Santa Maria Gastroenterology Medical Group

    Santa Maria, California 93458
    United States

    Site Not Available

  • Clinical Trials Management Services LLC

    Thousand Oaks, California 91360
    United States

    Site Not Available

  • Gastroenterology Center of Connecticut, PC

    Hamden, Connecticut 06518
    United States

    Site Not Available

  • West Central Gastroenterology

    Clearwater, Florida 33756
    United States

    Site Not Available

  • Homestead Associates In Research Inc

    Homestead, Florida 33032
    United States

    Site Not Available

  • Indian Health Service Health Research

    Kissimmee, Florida 34741
    United States

    Site Not Available

  • Lake Center for Clinical Research

    Lady Lake, Florida 32159
    United States

    Site Not Available

  • Auzmer Research

    Lakeland, Florida 33813
    United States

    Site Not Available

  • University of Miami Hospital and Clinic

    Miami, Florida 33136
    United States

    Site Not Available

  • Ocala Gastrointestinal Research, LLC

    Ocala, Florida 34471
    United States

    Site Not Available

  • AdventHealth Medical Group Gastroenterology and Hepatology

    Orlando, Florida 32804
    United States

    Site Not Available

  • Infigo Clinical Research

    Sanford, Florida 32771
    United States

    Site Not Available

  • Atlanta Gastroenterology Associates

    Atlanta, Georgia 30342
    United States

    Site Not Available

  • Columbus Regional Research Institute, LLC

    Columbus, Georgia 31901
    United States

    Site Not Available

  • Grand Teton Research Group

    Idaho Falls, Idaho 83404
    United States

    Site Not Available

  • Rush University Medical Center

    Chicago, Illinois 60612
    United States

    Site Not Available

  • Digestive Research Alliance of Michiana

    South Bend, Indiana 46635
    United States

    Site Not Available

  • University of Kansas Medical Center

    Kansas City, Kansas 66160
    United States

    Site Not Available

  • Mid-Atlantic GI Research, LLC

    Greenbelt, Maryland 20770
    United States

    Site Not Available

  • Harvard Medical School - Brigham and Womens Hospital

    Boston, Massachusetts 02115
    United States

    Site Not Available

  • University of Massachusetts Memorial Medical Center

    Worcester, Massachusetts 01655
    United States

    Site Not Available

  • University of Michigan

    Ann Arbor, Michigan 48109
    United States

    Site Not Available

  • University of Michigan Health System

    Ann Arbor, Michigan 48109
    United States

    Terminated

  • Clinical Research Institute of Michigan

    Troy, Michigan 48098
    United States

    Site Not Available

  • West Michigan Clinical Research Center

    Wyoming, Michigan 49519
    United States

    Site Not Available

  • Southern Therapy and Advanced Research LLC - Jackson

    Jackson, Mississippi 39216
    United States

    Site Not Available

  • Gastrointestinal Associates Research, LLC

    Columbia, Missouri 65201
    United States

    Site Not Available

  • Bvl Clinical Research

    Liberty, Missouri 64068
    United States

    Site Not Available

  • Interspond - Las Vegas Medical Research

    Las Vegas, Nevada 89113
    United States

    Site Not Available

  • Sanmora Bespoke Clinical Research Solutions

    East Orange, New Jersey 07018
    United States

    Site Not Available

  • Aga Clinical Research Associates LLC

    Egg Harbor Township, New Jersey 08234
    United States

    Site Not Available

  • Affiliates in Gastroenterology Digestive Disease Research

    Florham Park, New Jersey 07932
    United States

    Site Not Available

  • Atlantic Digestive Health Institute

    Morristown, New Jersey 07960
    United States

    Site Not Available

  • Premier Health Research LLC

    Sparta, New Jersey 07871
    United States

    Site Not Available

  • University of New Mexico

    Albuquerque, New Mexico 87106
    United States

    Site Not Available

  • New York University Grossman School of Medicine and New York University Langone Hospitals

    Lake Success, New York 11042
    United States

    Site Not Available

  • New York University Langone Medical Center

    Lake Success, New York 11042
    United States

    Active - Recruiting

  • Consultants for Clinical Research

    Cincinnati, Ohio 45219
    United States

    Site Not Available

  • Digestive Specialists Inc Research, LLC

    Springboro, Ohio 45066
    United States

    Site Not Available

  • Hightower Clinical

    Oklahoma City, Oklahoma 73102
    United States

    Site Not Available

  • Options Health Research, LLC

    Tulsa, Oklahoma 74104
    United States

    Site Not Available

  • Guthrie Robert Packer Hospital

    Sayre, Pennsylvania 18840
    United States

    Site Not Available

  • Medical University of South Carolina

    Charleston, South Carolina 29425
    United States

    Site Not Available

  • Columbia Digestive Health Research LLC

    Columbia, South Carolina 29204
    United States

    Site Not Available

  • Wake Research-ClinSearch, LLC

    Chattanooga, Tennessee 37421
    United States

    Site Not Available

  • Digestive Health Research, LLC

    Hermitage, Tennessee 37076
    United States

    Site Not Available

  • ANRC Research

    El Paso, Texas 79912
    United States

    Active - Recruiting

  • Anrc Research

    El Paso, Texas 79912
    United States

    Active - Recruiting

  • Great Lakes Research Insititute El Paso Research

    El Paso, Texas 79912
    United States

    Site Not Available

  • Digestive Health Associates

    Houston, Texas 77024
    United States

    Site Not Available

  • Digestive Research of Central Texas, LLC

    Waco, Texas 76712
    United States

    Site Not Available

  • Digestive Health Research of North Texas LLC

    Wichita Falls, Texas 76301
    United States

    Site Not Available

  • Emeritas Research Group

    Lansdowne Town Center, Virginia 20176
    United States

    Site Not Available

  • Blue Ridge Medical Research

    Lynchburg, Virginia 24502
    United States

    Site Not Available

  • GI Select Health Research LLC

    Richmond, Virginia 23236
    United States

    Site Not Available

  • Hunter Holmes McGuire Veterans Affairs Medical Center

    Richmond, Virginia 23249
    United States

    Site Not Available

  • Hunter Holmes McGuire Veterans Medical Center

    Richmond, Virginia 23249
    United States

    Active - Recruiting

  • North Richmond Health Research

    Richmond, Virginia 23229
    United States

    Site Not Available

  • Wisconsin Center for Advanced Research

    Milwaukee, Wisconsin 53215
    United States

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.