Whole Genome Sequencing (ChromoSeq) as an Adjunct to Conventional Genomic Profiling in AML and MDS

Last updated: October 14, 2025
Sponsor: Washington University School of Medicine
Overall Status: Active - Recruiting

Phase

N/A

Condition

Leukemia

Acute Myeloid Leukemia

Platelet Disorders

Treatment

ChromoSeq

Clinical Study ID

NCT04986657
202105123
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This is a single institution, prospective study of the whole genome sequencing assay, ChromoSeq. Using prospectively collected patient data, coupled with physician surveys, the investigators seek to determine the feasibility of implementing ChromoSeq in addition to standard genomic testing, for patients with the diagnoses of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).

Eligibility Criteria

Inclusion

Inclusion Criteria Patient

  • Patient with a clinical suspicion for a new diagnosis of AML or MDS for whom the diagnostic molecular testing via the hematologic molecular algorithm (HMA) at BJH is requested or planned to be requested.

  • Adult patients 18 years or older.

  • Ability to understand and willingness to sign an IRB approved written informed consent document.

Inclusion Criteria Physician

  • Treating physician at Washington University School of Medicine who directs therapy for individuals with hematologic malignancies.

  • Able and willing to complete standardized questionnaires about usability, and stakeholder perceptions of ChromoSeq during the ChromoSeq implementation process.

Exclusion Criteria Patient

  • Younger than 18 years of age

Exclusion Criteria Physician

  • Does not treat patients at Washington University School of Medicine

Study Design

Total Participants: 325
Treatment Group(s): 1
Primary Treatment: ChromoSeq
Phase:
Study Start date:
September 17, 2021
Estimated Completion Date:
December 31, 2027

Connect with a study center

  • Washington University School of Medicine

    Saint Louis, Missouri 63110
    United States

    Site Not Available

  • Washington University School of Medicine

    St Louis 4407066, Missouri 4398678 63110
    United States

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.