Effect of Electro-acupuncture on Women With Diminished Ovarian Reserve

Last updated: July 12, 2021
Sponsor: Huazhong University of Science and Technology
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT04972877
TJ-IRB20190620
  • Ages 18-40
  • Female

Study Summary

Diminished ovarian reserve (DOR) is the precursor state of ovarian failure, and can cause the decline of women's reproductive function. Some studies have demonstrated that acupuncture can improve ovarian function. In this trial, we hypothesize that electro-acupuncture is efficient for the ovarian function and the following outcome of IVF-ET in DOR patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Age < 40, will undergo IVF-ET;
  2. Low ovarian reserve: Antral follicle count (AFC)<7, or AMH<1.1ng/ml; or has a historyof poor ovarian response: in the last hyper stimulation cycle, the number of retrievedoocytes<3;
  3. Spouse' semen examination is normal, or after semen prewash can reach the standard ofcommon IVF or Intracytoplasmic Sperm Injection(ICSI).

Exclusion

Exclusion Criteria:

  1. Male with azoospermia;
  2. Male/female's chromosome is abnormal;
  3. Adenomyosis, uterine fibroids, endometrial polyps, scar uterine, reproductive systemtuberculosis, oviduct effusion, pelvic lesions such as ovarian endometriosis cyst ortumor;
  4. Female has other endocrine disease: thyroid diseases, hyperprolactinemia, insulinresistance, diabetes, adrenal diseases, etc.
  5. Definitively diagnosed autoimmune diseases such as systemic lupus erythematosus,rheumatoid arthritis, antiphospholipid syndrome;
  6. Other pathogenesis that leads to recurrent miscarriage or agnogenic recurrentmiscarriage;
  7. A history of cancer and has received radiotherapy and chemotherapy;
  8. Had acupuncture treatment in recent 3 months;
  9. Unwilling to sign the informed consent of this study.

Study Design

Total Participants: 338
Study Start date:
September 09, 2019
Estimated Completion Date:
December 31, 2025

Study Description

First, patients will be recruited according to the inclusion criteria and exclusion criteria.

Second, baseline measurements (including ovarian reserve function, blood biochemical index, scores from the self-rating anxiety and depression scale, quality of life) will be taken.

Third, each patient will receive 24 sessions of acupuncture in 2-3 months, twice or three times a week.

Last, the above baseline measurements will be taken again as soon as the treatment is finished and outcome measures will be recorded after the treatment.

Connect with a study center

  • Department of Integrated Traditional Chinese and Western Medicine Tongji hospital of Huazhong University of Science and Technology

    Wuhan, Hubei 027
    China

    Active - Recruiting

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