Efficacy of Estrogen-intrauterine Stent System After Intrauterine Adhesiolysis

Inclusion Criteria:

• Female patients aged 18-40 years;
• Meets the diagnostic criteria for moderate to severe uterine adhesions;
• Has the indication for TCRA surgery and is intending to undergo TCRAsurgery;
• Female subjects are not breastfeeding at the time of the screeningvisit; ⑤ Voluntary acceptance of the treatment and has signed theinformed consent form.

Exclusion Criteria:

• Known allergic reactions to or contraindications for silicone rubber materials,estradiol and its metabolites, Foley balloon catheters and/or intrauterinecross-linked sodium hyaluronate gel;
• Presence of contraindications for TCRA surgery;
• Requires oral hormonal medications for a prolonged period of time;
• Has used high-dose estrogen medication within one month prior tosurgery;
• Suffering from diseases such as genital tract tuberculosis, acutegenital tract inflammation, pelvic inflammatory disease, abnormaluterine bleeding caused by systemic disease or malignant tumoursof the genital organs; ⑥ Perimenopausal and menopausal females; ⑦ Comorbid with severe primary diseases of the cardiovascular,cerebrovascular, hepatic, renal or hematopoietic system, or pepticulcer disease, or severe diseases affecting patient survival (suchas tumours or AIDS), or mental illness; ⑧ Drug or alcohol dependence; ⑨ Has enrolled in other clinical trials within the last 1 month; ⑩ Patients with factors considered by the investigators to beunsuitable for enrollment.