Venetoclax + Cytarabine Versus Idarubicin + Cytarabine : Efficacity Assessment as Post-remission Therapy to Elderly Patients With Acute Myeloid Leukemia in First Remission

Inclusion Criteria :

• ≥ 60 years of age.

• AML de novo according to the WHO 2016 classification

• AML with favorable or intermediate cytogenetics according to ELN 2017

• Subjects should be eligible for intensive chemotherapy by Idarubicin, Cytarabine,and Lomustine (standard induction for FILO)

• SORROR < 3 (for the protocol, calculation of Sorror excludes a history of cancer) (appendix 2)

• AML secondary to MDS or chemotherapy are eligible, unless adverse cytogenetics

• Eastern Cooperative Oncology Group (ECOG) < 3 (appendix 1)

• Adequate baseline organ function defined by the criteria below:

• Adequate renal function as demonstrated by a creatinine clearance ≥ 50 mL/min;calculated by the Cockcroft Gault formula or measured by 24-hours urinecollection

• Aspartate aminotransferase (AST) ≤ 3.0 × upper limit of normal (ULN)

• Alanine aminotransferase (ALT) ≤ 3.0 × ULN

• Bilirubin ≤ 1.5 × ULN

• Adequate cardiac function with Left Ventricular Ejection Fraction (LVEF) ≥ 50 %

• Absence of any psychological, familial, sociological or geographical conditionspotentially hampering compliance with the study protocol and follow-up schedule

• Females must be menopausal to be pre-enrolled

• Patients must be affiliated to the French Social Security (health insurance)

• Signed written informed consent for the study

Exclusion Criteria:

• Diagnosis of Acute Promyelocytic Leukemia (APL)

• AML with adverse cytogenetics according to ELN 2017

• AML with BCR-ABL1 translocation

• Subject with an antecedent of myeloproliferative neoplasm (MPN) includingmyelofibrosis, essential thrombocytosis, polycythemia vera, or chronic myelogenousleukemia (CML) with or without BCR-ABL1 translocation

• Clinical symptoms suggesting active central nervous system leukemia, or presence ofisolated extramedullary leukemia

• Previous exposure of anthracycline ≥ 550 mg/m² (Daunorubicin equivalence)

• Previous AML treatment other than Hydroxyurea

• Treatment with an investigational drug within 30 days or 5 half-life whichever islonger, preceding the initiation study and/or previous treatment with Venetoclax

• History of another malignancy within the past 3 years except basal cell carcinoma ofthe skin or cervix in situ carcinoma

• Any serious medical condition, laboratory abnormalities or psychiatric illness thatwould place the participant at an unacceptable risk or prevent them from givinginformed consent or precluding the administration of protocol treatments

• Other comorbidity that the physician judges to be incompatible with conventionalintensive chemotherapy which must be reviewed and approved by the study medicalmonitor before study enrolment

• Subject with known HIV infection (due to potential drug-drug interactions betweenantiretroviral medications and Venetoclax). HIV testing will be performed atScreening. Subject known to be positive for hepatitis B virus (HBV) or hepatitis Cvirus (HCV) infection. Inactive hepatitis carrier status with undetectablePolymerase Chain Reaction (PCR) viral load on antivirals (non-exclusionarymedications) are not excluded.

Randomization criteria:

1. Subjects must have been registered at diagnosis

2. Subjects must have received intensive induction by Idarubicin, Cytarabine andLomustine

3. Patients in Complete Response / Complete Response with incomplete hematologicrecovery (CR/CRi) post induction according to ELN 2017 criteria

4. Randomization should be performed no more than D+60 after induction

5. ECOG < 3 (appendix 1)

6. Adequate baseline organ function defined by the criteria below:

• Adequate renal function as demonstrated by a creatinine clearance ≥ 50 mL/min;calculated by the Cockcroft Gault formula or measured by 24-hours urinecollection

• Aspartate aminotransferase (AST) ≤ 3.0 × ULN

• Alanine aminotransferase (ALT) ≤ 3.0 × ULN

• Bilirubin ≤ 1.5 × ULN

7. Adequate cardiac function with LVEF ≥ 50 %

8. Male subjects who are sexually active must agree, from study Day 1 through at least 180 days after the last dose of study drug, to practice protocol-specified methodsof contraception

9. Female subjects must be postmenopausal defined as with no menses for 12 or moremonths without an alternative medical cause

Non randomization criteria

1. Patient in Partial Remission (PR) or failure following one induction course byIdarubicin, Cytarabine and Lomustine (according ELN 2017 criteria)

2. Uncontrolled infection

3. Subject with cardiovascular disability status as per New York Heart AssociationClass > 2. Class 2 is defined as cardiac disease in which subjects are comfortableat rest but ordinary physical activity results in fatigue, palpitations, dyspnea, orangina pain. Class 3 is defined as cardiac disease in which subjects are comfortableat rest but less than ordinary activity causes fatigue, palpitation, or dyspnea.Class 4 is defined as cardiac disease in which subjects have an inability to carryon any physical activity without discomfort, symptoms of heart failure at rest, andif any physical activity is undertaken then discomfort increases.

4. Subject has a malabsorption syndrome or other condition that precludes enteral routeof administration.

5. Any serious medical condition, laboratory abnormality, or psychiatric illness thatwould place the participant at an unacceptable risk or prevent them from givinginformed consent.

6. Treatment with any of the following within 7 days prior to the first dose of studydrug :

• Strong or moderate CYP3A inducers

• Steroid therapy for anti-neoplastic intent

7. Subject having consumed grapefruit, grapefruit products, Seville oranges (includingmarmalade containing Seville oranges) or Star fruit within 3 days prior to theinitiation of study treatment.

8. Subject having chronic respiratory disease that requires continuous oxygen, or asignificant history of renal, neurologic, psychiatric, endocrinologic, metabolic,immunologic, hepatic, cardiovascular disease, any other medical condition that inthe opinion of the investigator would adversely affect his/her participating in thisstudy.

9. Previous treatment with Venetoclax and/or current participation in any otherresearch study with investigational products.

10. Known hypersensitivity to the study medication