Gender/Sex & CUD Remission

Last updated: November 6, 2025
Sponsor: Medical University of South Carolina
Overall Status: Completed

Phase

N/A

Condition

Follicular Lymphoma

Substance Abuse

Treatment

Cognitive Behavioral Therapy (CBT4CBT)

Clinical Study ID

NCT04964739
00110801
R01DA054617
  • Ages > 18
  • All Genders

Study Summary

Adults (ages 18+) who would like to reduce their cannabis use (N=224) will be enrolled in an 8-week treatment program. All participants will receive counseling (1 goals session with a therapist followed by 7 weekly computerized cognitive-behavioral therapy sessions). Detailed cannabis assessments (biological and self-report) will be conducted throughout treatment and at 1-, 2-, and 3-months post-treatment completion. Daily electronic diaries will be administered via text message to record detailed logs of cannabis use quantity and frequency. Salivary samples will be collected (and video observed) daily throughout treatment to analyze for progesterone.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Willingness to participate in a research study (otherwise, will be referred toappropriate clinical services if seeking clinical care).

  2. Meet current (within last 30 days) DSM-5 criteria for cannabis use disorder.

  3. Submit a positive urine cannabinoid test during screening.

  4. Interested in treatment for cannabis use disorder.

Exclusion

Exclusion Criteria:

  1. Significant or acutely unstable medical or psychiatric problems (i.e., psychosis,mania) that would contraindicate research procedures, interfere with safety,compromise data integrity, or preclude consistent study participation.

  2. The presence of any substance use disorder requiring a higher level of care.

  3. Significant risk of homicide or suicide.

  4. Pregnant, trying to become pregnant, or breastfeeding.

Study Design

Total Participants: 224
Treatment Group(s): 1
Primary Treatment: Cognitive Behavioral Therapy (CBT4CBT)
Phase:
Study Start date:
November 15, 2021
Estimated Completion Date:
October 27, 2025

Connect with a study center

  • Medical University of South Carolina

    Charleston, South Carolina 29425
    United States

    Site Not Available

  • Medical University of South Carolina

    Charleston 4574324, South Carolina 4597040 29425
    United States

    Site Not Available

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