Efficacy of Jessener Solution Versus Intralesional Steroid in Treatment of Alopecia Areata

Last updated: July 13, 2021
Sponsor: Al-Azhar University
Overall Status: Active - Recruiting

Phase

1

Condition

Alopecia

Hair Loss

Treatment

N/A

Clinical Study ID

NCT04964349
Alazhar faculty of medicine
Eman Abd-ellatif
Ahmed Kadah
  • Ages 12-40
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Alopecia areata is believed to be an autoimmune disease. Treatment primarily relies on intralesional and topical corticosteroids. This study was conducted to evaluate Jessener Solutionas a potential therapeutic modality of Alopecia Areataversusintralesional steroid as regards the efficacy, safety, tolerability, and patients' satisfaction.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 1.Alopecia Areatamultilocuolaris.2.Age from18-50years old. 3.Wash out period is twomonths. 4.Ophiasis pattern alopecia areata.

Exclusion

Exclusion Criteria:

  • Age less than 12 yearsand more than 40years old. 2.Patient under treatment.3.Patientshaving another dermatological condition affecting thescalpas eczema.4.Patients withpsychiatric disorders.5.Pregnant and lactating females.

Study Design

Total Participants: 40
Study Start date:
April 21, 2021
Estimated Completion Date:
November 20, 2021

Study Description

Background Alopecia areata is believed to be an autoimmune disease resulting from a breach in the immune privilege of the hair follicles causing non scarring hair loss.Treatment primarily relies on intralesional and topical corticosteroids.Up till now, there is nouniversally proven therapy that induces and maintains remission of Alopecia Areata in all patients.

Aims The Aim of Study is to evaluate the efficacyof Jessener solution versus intralesional steroid in treatment of Alopecia Areata.

Patients and Methods The study will include 40 patients diagnosed clinically and dermoscopically as Alopecia Areata with more than two patches of alopecia areata were included. Two treatment modalities with intralesional corticosteroid and topical Jessener Solutionas were performed in two randomly selected patches. Three sessions were done, 3 weeks apart and were followed-up for three months. Evaluation was done using Mac Donald Hull and Norris grading system , Serial photographs and dermoscopic , trichoscopic examination every month will be done and patient will be score.

Connect with a study center

  • Alazhar faculty of meidicine

    Cairo,
    Egypt

    Active - Recruiting

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