Phase
Condition
Mental Disability
Memory Loss
Mild Cognitive Impairment
Treatment
Physical activity program
Successful Aging
Clinical Study ID
Ages > 60 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
are African American (self-identify)
are 60 and older
are physically capable of exercise
are willing to accept randomization
are willing to attend group sessions
plan to live in the study area over the next 13 months and capable of traveling todesignated study facility for clinic visits and intervention sessions for the nextyear
are free of conditions (e.g. uncontrolled asthma, severe sickle cell disease, etc.)that would make regular exercise unsafe as deemed by the medical investigator
have not engaged in regular physical activity
have a Short Physical Performance Battery ≥4
physically capable of exercise
are unable to utilize devices and/or applications as required for studyparticipation
willing to attend group sessions
willing to allow researchers to use data for research purposes after studyparticipation is completed
meet criteria for MCI as defined by the NIA-AA research framework a. cognitiveperformance below normal range (score < 1.5 SDs below the mean on NIH Toolbox scoresfor their age and sex on at least one of the subtests)
Exclusion
Exclusion Criteria:
have cognitive impairment that would interfere with participating in a groupdiscussion a. cognitive performance in the demented range (score < 3 SDs below the mean on NIHToolbox scores for their age and sex on at least one of the subtests)
meet criteria for dementia
are unwilling to give written informed consent or accept randomization in eitherstudy group
are too active (as defined by ≥10 min bouts of MVPA as measured by Actigraph) if:
Sum of MVPA bouts for the 7 day wear period ≥40 mins
Or ≤40 mins of MVPA 10min bouts AND ≥3 days of bouts
have uncontrolled hypertension (systolic blood pressure > 150 mmHg and/or diastolicblood pressure > 90 mmHg).
have had a myocardial infarction, major heart surgery (i.e., valve replacement orbypass surgery), stroke, deep vein thrombosis, pulmonary embolus, hip fracture, hipor knee replacement, or spinal surgery in the past 6 months
are undergoing cardiopulmonary rehabilitation
have uncontrolled diabetes that in the judgment of the MI may interfere with studyparticipation
have clinically diagnosed osteoporosis that in the judgment of the MI may interferewith study participation
are currently enrolled in another randomized trial involving lifestyle orpharmaceutical interventions
have another member of the household that is a participant in RAATE or RAATE MCI
refuse to participate in the study without disclosure of their amyloid PET scanresults
refuse to allow anonymized versions of their study data for research after thisstudy is completed.
have other medical, psychiatric, or behavioral factors that in the judgment of thePrincipal or Medical Investigator may interfere with study participation or theability to follow the intervention protocol
Study Design
Study Description
Connect with a study center
Pennington Biomedical Research
Baton Rouge, Louisiana 70808
United StatesActive - Recruiting
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