Comparative Study of APRF/CGF Technology in GTR

Last updated: July 6, 2021
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Periodontitis

Treatment

N/A

Clinical Study ID

NCT04953260
2020-1021
  • Ages 18-80
  • All Genders

Study Summary

Guided tissue regeneration(GTR) uses membranous materials to shield gingival epithelial cells and connective tissue cells which grow more rapidly, creating an effective closed space and time for periodontal ligament cells with regenerative potential, so that new cementum is formed on the root surface and periodontal ligament fibers are embedded, resulting in regenerative healing. In order to improve the effect of periodontal regeneration therapy, as early as 1990s, scholars began to mix platelet concentrate and bone graft in periodontal regenerative surgery to improve the ability of local bone induction and tissue healing. Studies have shown that platelet concentrate, which is rich in a variety of growth factors in autologous blood, can promote soft tissue and bone tissue healing by acting on tissue healing cells (osteoblasts, epithelial cells, connective tissue cells, etc.). It is closely related to periodontal regeneration; the regenerative component of platelet concentrate, growth factor, and the structure of fibrin network containing growth factor are the key to promote tissue repair and regeneration.Modified platelet-rich fibrin (advanced platelet rich fibrin,APRF) and concentrated growth factor (CGF) are the latest generation of platelet concentrates. A number of studies have shown that APRF and CGF contain more cytokines, have a denser fibrin network, and show stronger ability to promote the migration and proliferation of gingival fibroblasts, suggesting that both of them may have better ability to promote bone tissue healing. At present, the latest generation of platelet concentrate has been widely used in implant surgery, but their clinical effects in periodontal regeneration surgery are still lack of conclusive evidence. there is no report on comparing the clinical effects of the two through randomized clinical controlled trials.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. The age of the patient is 18-80 years old.
  2. selection of affected teeth: there is still at least one site of periodontal probingdepth ((PD) ≥ 5mm) at 6-8 weeks after initial periodontal treatment,and the degree ofmobility is less than grade II or II-III degree but without mobility afterfixation.Imaging evaluation shows that the tooth has a Intrabony defect which islarger than 3mm, and there is no history of periodontal surgery at this site, and theaffected tooth has no obvious symptoms of discomfort.
  3. The patient has good compliance, good plaque control after basic treatment (bleedingindex and plaque index < 20%). He/She can understand the purpose of the test and iswilling to cooperate with surgical treatment and follow-up. He/She voluntarilyparticipates in the trial and signs informed consent.

Exclusion

Exclusion Criteria:

  1. In the past 6 months, patients who chewed smokeless tobacco, smoked a pipe or cigaronce a week, or smoked more than 20 cigarettes per week (1 pack per week);
  2. Patients took any drug affecting platelet function or had a platelet count less than 200000/mm3 3 months before blood collection.
  3. Patients have taken antiepileptic drugs, antihistamines, antidepressants, sedatives,sedatives, anti-inflammatory drugs or daily analgesics within 1 month beforeoperation;
  4. Patients with a history of diabetes or patients with abnormal blood glucose test (fasting blood glucose ≥ 7mmol/L);
  5. Liver and renal dysfunction (AST, ALT ≥ 1.5 times ULN, creatinine ≥ 1.5 times ULN);
  6. Patients with severe endocrine and metabolic diseases.
  7. Those with a history of grade 3 hypertension;
  8. Those with a history of osteoporosis;
  9. Those with a history of autoimmune diseases;
  10. Those with a history of malignant tumor or other serious diseases who are not suitablefor surgery or cause observation of tooth loss;
  11. Pregnant or lactating women;
  12. Patients with local anesthetic allergy.
  13. Clinical or radiological findings showed acute infection, apical lesions, rootfractures, severe root deformities, cementum beads, indelible enamel protuberances,untreated caries at the enamel or root boundary, and restoration reaching subgingivaland/or below CEJ or marginal incongruity
  14. All kinds of subjects who can cause artifacts in oral imaging examination, such as:the study teeth and their adjacent teeth are metal dentures and porcelain teeth;
  15. The affected teeth have root furcation lesions

Study Design

Total Participants: 78
Study Start date:
August 25, 2020
Estimated Completion Date:
March 31, 2022

Connect with a study center

  • Lei Lihong

    Hangzhou,
    China

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.