Enalapril Folic Acid Tablets Combined With CCB or Diuretic to Prevent Stroke in Patients With Type H Hypertension

Phase

Condition

Vascular Diseases

Williams Syndrome

Stress

Treatment

N/A

Clinical Study ID

NCT04952051

2014-132

Ages 40-75
All Genders

Study Summary

Hypertension is a common condition that can cause serious events such as stroke, coronary heart disease and heart failure. Homocysteine (Hcy) is a substance in the body that is harmful to blood vessels. Hyperhomocysteinemia (plasma Hcy≥10 mol/L), which is associated with hypertension, significantly increases the risk of stroke. This type of high blood pressure is called type "H" hypertension. Enalapril folic acid tablet is an innovative drug developed independently in China and is the first choice for the treatment of H type hypertension. Patients with type H hypertension should be treated with enalapril folic acid tablets to reduce stroke.

However, some patients had poor blood pressure control after monotherapy. At this time, other antihypertensive drugs should be used in combination. Amlodipine and Hydrochlorothiazide are the most commonly used and the best combination.

The purpose of this study was to observe the difference in the efficacy of enalapril folic acid tablets in patients with uncontrolled blood pressure who were well tolerated and randomized to aminoclodipine or hydrochlorothiazide in reducing stroke and other cardiovascular and cerebrovascular events, and to explore the relationship between various alternative measures and efficacy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

1.40-75 years old (inclusive);
1. Patients who have been diagnosed with all types of essential hypertension (thosewho are currently taking antihypertensive drugs with normal blood pressure can stillbe admitted) or those whose blood pressure screening meets the inclusion criteria;
1. Plasma (or serum) Hcy 10 mol/L;
1. Enalapril folic acid tablet 10.8 mg/day alone is not up to standard;
1. In the case of women of reproductive age, agree to use a reliable method ofcontraception during the trial;
1. Participate voluntarily and sign the informed consent;

Exclusion

Exclusion Criteria:

1. Previous stroke with definite diagnosis;
1. Patients with previous well-diagnosed myocardial infarction;
1. The presence of well-diagnosed heart failure;
1. Postoperative revascularization;
5.DBP >=110 mmHg or SBP >=180 mmHg;
1. Confirmed secondary hypertension;
1. Severe physical and systemic disease, which is estimated to be unable to completethe follow-up;
1. People with known congenital or acquired organic heart disease;
1. People who have had obvious intolerable adverse reactions to ACEI drugs in thepast;
1. Have contraindications to ACEI drugs (including renal failure) or are allergic tothe drugs used in the study or other ingredients in the drugs;
1. According to the researchers, there are contraindications to the use of folicacid;
1. Pregnant and lactating women;
1. If there are other obvious laboratory tests, abnormal physical signs and clinicaldiseases, it is not suitable to participate in the study according to the researcher'sjudgment;
1. Unwilling to participate in the trial, unwilling or unable to change the existingmedication regimen;
1. Long-term use of folic acid or health medicines containing folic acid;
16.Severe mental disorder, unable to express their will

Study Design

July 01, 2014

July 01, 2020

Connect with a study center

Second affiliated Hospital Zhejiang University School of Medicine
Hangzhou, Zhejiang 310009
China
Site Not Available

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