Efficacy of Paper-based Cognitive Training in Vietnamese Patients With Early Alzheimer's Disease

Inclusion Criteria:

• For patient:

• Diagnosis of Probable Alzheimer's Disease per DSM-5 criteria;

• In the early stage of AD (MMSE from 20 to 25);

• Age from 60 - 80 years old;

• Had greater than 5 years of formal education.

• For Caregiver:

• Members (including, but not limited to partners, children, relatives, lived-inhelper of the patient) that are important for care delivery and providecare-related tasks (eg personal care, eating, cooking, cleaning) and everydaydecision making to the patients. They are not required to live together orspend a specific amount of time with the patients;

• Older than 18 years of age;

• Possess adequate Vietnamese language skills and no cognitive impairment toconduct interview and evaluation

Exclusion Criteria:

• For patient:

• Patients with concomitant diseases (heart failure, kidney failure, liverfailure or thyroid diseases) that affect cognitive functions;

• Diagnosed with significant neurologic disease other than AD (Parkinson'sdisease, multi-infarct dementia, schizophrenia, history of significant headtrauma followed by persistent neurologic defaults, …), major depression withinthe past 1 year, or taking psychoactive medications (antidepressants withsignificant anticholinergic side effects, neuroleptics, chronic anxiolytics orsedative hypnotics, etc) within the past 1 month;

• Having major visual, auditory, reading, or writing impairments;

• Patients and/or caregivers who decline to participate.

• For cargiver:

• Having subjective complaints of cognitive impairment prevents them fromunderstanding the instruction from the research team;

• Having significant visual, auditory, reading, or writing impairments;

• Caregivers who decline to participate