Potential Benefits of Laser Treatment on Skin Blood Flow and Sweating in Burn Survivors

Last updated: March 4, 2025
Sponsor: University of Texas Southwestern Medical Center
Overall Status: Terminated

Phase

N/A

Condition

Skin Wounds

Hyponatremia

Treatment

fractional CO2 laser

Clinical Study ID

NCT04947449
STU-2021-0241
  • Ages 18-65
  • All Genders

Study Summary

The purpose of this study is to examine effects of laser therapy on blood flow and sweating responses in burn-injured skin.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 18-65 years old

  • Experience a severe burn injury that warrant laser therapy.

  • Free of any significant underlying medical problems based upon a detailed medicalhistory and physical exam

Exclusion

Exclusion Criteria:

  • Known heart disease

  • Other chronic medical conditions requiring regular medical therapy including cancer,diabetes, uncontrolled hypertension, and uncontrolled hypercholesterolemia.

  • Abnormality detected on routine screening suggestive of cardiac ischemia orpreviously undetected cardiac disease or resting left bundle branch block onscreening electrocardiogram.

  • Subject with a body mass index >35 kg/m2

  • Pregnant or planning to become pregnant within the subsequent 6 months.

Study Design

Total Participants: 4
Treatment Group(s): 1
Primary Treatment: fractional CO2 laser
Phase:
Study Start date:
July 29, 2021
Estimated Completion Date:
March 01, 2025

Study Description

This is a longitudinal study in which the effects of laser therapy on cutaneous vascular responses and sweating of the treated areas are assessed. Specifically, burn survivors who will undergo standard of care laser therapy to treat burn-related scars will perform whole-body heating and local heating procedures prior to the initiation of laser therapy, at an intermediate point during the laser therapy regimen, and upon conclusion of the laser therapy regimen.

For this pilot investigation a placebo will not be incorporated.

Primary outcome variables will be skin blood flow and sweating responses from skin treated with laser therapy and adjacent untreated/uninjured skin.

Connect with a study center

  • University of Texas Southwestern Medical Center

    Dallas, Texas 75390
    United States

    Site Not Available

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