Poor Grade Aneurysmal Subarachnoid Hemorrhage Study Group

Last updated: November 24, 2023
Sponsor: IRCCS San Raffaele
Overall Status: Active - Recruiting

Phase

N/A

Condition

Stroke

Hemorrhage

Treatment

Standard management according to international/national guidelines

Clinical Study ID

NCT04945603
POGASH
  • Ages > 18
  • All Genders

Study Summary

Multicentric registry study in order to define outcome, predictors, treatment effects and their modifiers in poor grade aneurysmal subarachnoid haemorrhage patients.

The search for outcome predictors is going to be subdivided into three main research areas:

  1. outcome predictors in the emergency department (so called "early brain injury phase").

  2. outcome predictors in the neurocritical care unit (so called "delayed brain injury phase").

  3. Treatment strategies. Two other areas of research are identified: delayed cerebral ischemia (incidence, treatment, predictors, impact on outcome) and long term follow-up (recent evidences suggest that there may be a non-negligible proportion of poor grade subarachnoid hemorrhage patients who may benefit from substantial improvement at long-term (after 6-12 months of follow-up).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients admitted to the emergency department because of aneurysmal subarachnoidhemorrhage of poor grade (IV-V) according to the WFNS classification.

Exclusion

Exclusion Criteria:

  • Patients younger than 18 years old.
  • Pregnant or breast-feeding patients.
  • Aneurysmal subarachnoid hemorrhage due to trauma or vascular malformations other thancerebral aneurysms.

Study Design

Total Participants: 800
Treatment Group(s): 1
Primary Treatment: Standard management according to international/national guidelines
Phase:
Study Start date:
May 25, 2021
Estimated Completion Date:
December 31, 2028

Connect with a study center

  • ASST Ospedale Papa Giovanni XXIII

    Bergamo, 24127
    Italy

    Site Not Available

  • IRCCS Bellaria

    Bologna,
    Italy

    Active - Recruiting

  • Azienda Ospedaliera Spedali Civili

    Brescia, 25123
    Italy

    Active - Recruiting

  • Ospedale Vito Fazzi

    Lecce, 73100
    Italy

    Active - Recruiting

  • IRCCS San Raffaele

    Milano, 20134
    Italy

    Active - Recruiting

  • Ospedale Maggiore della Città di Novara

    Novara,
    Italy

    Active - Recruiting

  • Azienda Ospedaliero-Universitaria di Parma

    Parma, 43126
    Italy

    Active - Recruiting

  • Policlinico Universitario Agostino Gemelli

    Roma, 00168
    Italy

    Site Not Available

  • Ospedale Santissima Annunziata

    Taranto, 74121
    Italy

    Active - Recruiting

  • Azienda Ospedaliera Universitaria Integrata

    Verona, 37126
    Italy

    Active - Recruiting

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