Study of Safety and Efficacy of ANG-3070 in Chronic Kidney Disease

Inclusion Criteria:

1. Male or female participants aged 18 and older.
2. Diagnosis of a primary glomerular disease confirmed from a past renal biopsy.Participants with genetic forms of FSGS may be enrolled without a renal biopsy if theclinical picture is consistent with the genetic testing results.
3. Estimated glomerular filtration rate (eGFR) by Chronic Kidney Disease EpidemiologyCollaboration (CKD-EPI) ≥ 40 mL/min/1.73m2.
4. Urinary protein excretion ≥ 1 g/day on a 24-hour urine collection.
5. All participants must be on the SOC therapy, including the maximallytolerated/recommended doses of an ACEi or ARB, but not both.

Exclusion Criteria:

1. Positive Hepatitis B (HBV), Hepatitis C (HCV), or human immunodeficiency virus (HIV)viral screening; historical or during screening.
2. Aspartate Aminotransferase (AST) or alanine Aminotransferase (ALT) or total bilirubin > 2 x ULN.
3. Hemoglobin A1C > 8.5%.
4. Known predisposition to bleeding and/or thrombosis
5. Type I diabetes mellitus.
6. Renal disease secondary to systemic disease including but not limited to: systemiclupus erythematosus, anti-neutrophil cytoplasmic antibodies -associated diseases,anti-glomerular basement disease, secondary forms of focal segmentalglomerulosclerosis, renal diseases associated with para-proteinemias, C3glomerulopathy, and diabetic kidney disease.