Isometric Exercise for People With Raised Blood Pressure

Last updated: September 14, 2023
Sponsor: East Kent Hospitals University NHS Foundation Trust
Overall Status: Completed

Phase

N/A

Condition

Vascular Diseases

Circulation Disorders

Williams Syndrome

Treatment

Standard care lifestyle advice

Isometric Exercise

Clinical Study ID

NCT04936022
NIHR200485
13472393
  • Ages > 18
  • All Genders

Study Summary

High blood pressure affects many people in the United Kingdom. People with raised blood pressure (140-159/90-99 mmHg) are recommended to make changes in their lifestyle (e.g. smoking/alcohol/diet/exercise) and/or medication in order to reduce their blood pressure. Current knowledge suggests that a particular type of exercise - isometric exercise - can lower blood pressure. Isometric exercise involves holding a fixed body position for a short period of time. As most of the information about the benefits of this type of exercise comes from laboratory-based studies, researchers want to find out if it is possible for GP practices to offer NHS patients with clinically high blood pressure an isometric exercise plan to do at home and how it might affect their blood pressure over 6 months. They will also find out the experiences of those doing this type of exercise and whether it can be done consistently at home over time.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Aged 18 or over
  • Clinic systolic BP 140-159 mmHg
  • Able to provide informed consent

Exclusion

Exclusion Criteria:

  • Currently taking anti-hypertensive medication
  • White coat hypertension, as evidenced by averaged home systolic BP <135 mmHg
  • Inability to undertake study intervention (isometric exercise)
  • Previous history of any of the following:
  • Diabetes mellitus (Type 1 or type 2)
  • Ischaemic heart disease (myocardial infarction and/or coronary angina and/orcoronary revascularization procedure)
  • Moderate or severe stenotic or regurgitant heart valve disease
  • Atrial or ventricular arrhythmia
  • Stroke or transient ischaemic attack
  • Aortic aneurysm and/or peripheral arterial disease
  • Uncorrected congenital or inherited heart condition
  • Estimated glomerular filtration rate <45 ml/min (calculated using CKD-EPI or MDRDformulae, and taking most recent documented results)
  • Documented left ventricular ejection fraction <45% and/or left ventricular hypertrophy (by either echocardiography or standard ECG criteria e.g. Sokolow-Lyon)
  • Documented urine albumin:creatinine ratio >3.5 mg/mmol
  • Inability to provide informed consent
  • If female, pregnancy or currently breast feeding
  • Enrolled in another Clinical Trial of an Interventional Medicinal Product or MedicalDevice or other interventional study
  • Medical condition that, in the opinion of the investigator, would make the participantunsuitable for the study

Study Design

Total Participants: 84
Treatment Group(s): 2
Primary Treatment: Standard care lifestyle advice
Phase:
Study Start date:
February 01, 2020
Estimated Completion Date:
November 30, 2022

Connect with a study center

  • Canterbury Medical Practice

    Canterbury, Kent CT45BL
    United Kingdom

    Site Not Available

  • Kent and Canterbury Hospital

    Canterbury, Kent
    United Kingdom

    Site Not Available

  • Northgate Medical Practice

    Canterbury, Kent CT11WL
    United Kingdom

    Site Not Available

  • Newton Place Surgery

    Faversham, Kent ME138FH
    United Kingdom

    Site Not Available

  • St Helier Hospital

    Carshalton, Surrey SM51AA
    United Kingdom

    Site Not Available

  • Maywood Healthcare Centre

    Bognor Regis, West Sussex PO212UW
    United Kingdom

    Site Not Available

  • Brighton Health and Wellbeing Centre

    Hove, BN31AE
    United Kingdom

    Site Not Available

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.