High Dose Omeprazole in Patients With Pancreatic Cancer

Inclusion Criteria:

• Newly diagnosed exocrine pancreatic cancer with either pathology, histology, orradiology imaging documented as adenocarcinoma

• Patient is a candidate for surgical resection of pancreatic cancer

• ≥ 18 years old at the time of informed consent

• ECOG Performance Status 0-2

• Patients with or without neoadjuvant chemotherapy will be eligible

• Ability to provide written informed consent and HIPAA authorization

• Women of childbearing potential definition must have a negative pregnancy testwithin 14 days of registration. All women (regardless of sexual orientation, havingundergone a tubal ligation, or remaining celibate by choice) are considered to havechildbearing potential unless they meet one of the following criteria:

• Prior hysterectomy or bilateral oophorectomy;

• Has not had menses at any time in the preceding 24 consecutive months

• Candidate for surgery per standard of care of per surgeon's discretion

Exclusion Criteria:

• Patients with pancreatic malignant tumor histologically confirmed as neuroendocrineor any other type of malignancies

• Positive pregnancy test, pregnant, or breastfeeding

• Known hypersensitivity to any component of the formulation or substitutedbenzimidazoles

• Any other clinically significant laboratory abnormality that would compromisepatient safety or the outcome of the study

• Any clinically significant and/or uncontrolled cardiac-related abnormality thatwould compromise patient safety or the outcome of the study

• Medical condition that might affect the absorption of study medications in theopinion of the investigator.