The Effect of Micro Fragmented Adipose Tissue (MFAT) on Shoulder Osteoarthritis

Inclusion Criteria:

• Age between 25 and 75 years-old

• Diagnosis of pre-existing osteoarthritis of the glenohumeral joint

• Working understanding of the English language and able to fully understand theprocedure

• Capable of providing informed consent

• Able to complete online, in-person or phone surveys for the purposes of follow-up

• Capable of understanding pre- and post-procedure care instructions

• Ambulatory at baseline

• Previous trial and failure of conservative therapy consisting of a minimum of 6weeks of physical therapy and trial of anti-inflammatory medications if notcontraindicated, with or without concomitant bracing and/or injections.

Exclusion Criteria:

• Age < 25 or > 75 years old

• Radiographs demonstrating either no, little osteoarthritis, severe(bone on bone)osteoarthritis

• Prior total or partial joint replacement surgery or surgery involving cartilageregeneration

• Previous cortisone, PRP or Hyaluronic acid intra-articular injection within the last 3 months

• Co-morbidity with the rheumatologic condition, inflammatory arthritis

• Currently undergoing immunomodulatory therapy

• Uncontrolled endocrine disorder

• BMI >40 or joint space not visible by ultrasound

• Current diagnosis of osteomyelitis, human immunodeficiency virus (HIV-1, -2) and/orhepatitis C (HCV), infection, and poorly controlled diabetes (HgA1C >7.0)

• Pregnancy or planned pregnancy

• previous stem cell injection into treatment joint

• Patient scheduled to undergo any concomitant shoulder surgical procedures or othersurgery which may affect outcomes.

• Coagulopathy or anticoagulant treatment

• Chronic pain involving multiple body parts or opioid medication management

• Diagnosis of fibromyalgia

• Concomitant massive(2 tendons with retraction), complete rotator cuff tendon tear