Efficacy and Safety of Losartan/Chlorthalidone vs Losartan/Hydrochlorothiazide in Essential Arterial Hypertension

Inclusion Criteria:

• Any sex.

• That they agree to participate in the study and give their informed consent inwriting.

• Age between 18 and 65 years old at the beginning of the study.

• Patients with essential arterial hypertension with BP ≥140 / 90 mmHg and <180/110mmHg.

• Women of childbearing potential using a contraceptive method (barrier, oralhormonal, injectable, subdermal), menopausal or surgically sterile.

Exclusion Criteria:

• The drug is contraindicated for medical reasons.

• Glomerular filtration rate ≤30 ml / min x 1.73 m2.

• Hypersensitivity to any of the components of the formula or other sulfonamides.

• Patients treated with other diuretics.

• Patient with a history of vascular disease (cerebrovascular disease, acute coronarysyndrome, etc.) and acute renal failure in the last 6 months.

• Patient with severe complications of type 2 diabetes mellitus (Ketoacidosis orhyperosmolar nonketotic coma).

• Patients participating in another clinical study involving an investigationaltreatment or participated in one in the previous 4 weeks.

• Positive pregnancy test, women who are pregnant, breastfeeding or planning apregnancy while conducting the study.

• Oncological patients (except basal cell skin cancer) or with serious diseases that,in the opinion of the investigator, have a serious prognosis or a life expectancy ofless than 1 year, as well as mental illnesses.

• Patients diagnosed with gout.

• Patients whose participation in the study may be influenced (employment relationshipwith the research center or sponsor, inmates, etc.).