Tau PET Imaging With 18F-T807(AV1451) in Neurodegenerative Disorders

Last updated: November 23, 2021
Sponsor: First Affiliated Hospital of Fujian Medical University
Overall Status: Active - Recruiting

Phase

1

Condition

Multiple Sclerosis

Neuronal Ceroid Lipofuscinoses (Ncl)

Neurologic Disorders

Treatment

N/A

Clinical Study ID

NCT04926259
MRCTA, ECFAH of FMU [2021]129
  • Ages 18-90
  • All Genders

Study Summary

Alzheimer's disease, Parkinson's disease, and Huntington's disease are common neurodegenerative diseases. Tau is a microtubule-associated protein, and aggregated tau resulting from hyperphosphorylation is a pathological feature of a group of neurodegenerative diseases known as tauopathies. The 18F-T807 (AV1451) molecular probe is a novel molecularly targeted imaging agent that exhibits high affinity and good selectivity for tau.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients or their families complain of significant memory impairment;
  • Objective memory impairment (e.g., tests of article identification, recall, delayedmemory);
  • Be able to obtain complete diagnosis and treatment records and be able to carry outlong-term follow-up;
  • Signed written consent.

Exclusion

Exclusion Criteria:

  • Psychiatric disorders: including anxiety disorder, affective disorder, severepsychosis, or drug-induced psychosis;
  • Pregnancy or lactation.

Study Design

Total Participants: 50
Study Start date:
November 01, 2021
Estimated Completion Date:
December 01, 2024

Study Description

In this study, 18F-T807 (AV1451) molecular probe PET/CT was used to monitor the regional distribution and the degree of deposition in patients with neurodegenerative diseases, and compared with clinical symptoms to evaluate its value in the early differential diagnosis of neurodegenerative diseases.

Connect with a study center

  • Department of Nuclear Medicine, First Affiliated Hospital of Fujian Medical University

    Fuzhou, Fujian 350005
    China

    Active - Recruiting

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