Goal-directed CPR Using Cerebral Oximetry

Last updated: March 24, 2025
Sponsor: NYU Langone Health
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Organ Transplant

Occlusions

Treatment

Non-Physiological Feedback CPR

Physiological Feedback CPR

Clinical Study ID

NCT04924985
20-00354
1R01HL151732-01
  • Ages 18-80
  • All Genders

Study Summary

The proposed study is a single-center, randomized controlled pilot trial of adults who suffer in-hospital cardiac arrests. Using cerebral oxygenation and end-tidal carbon dioxide physiological targets to predict survival and neurological outcome, the impact of physiological-feedback CPR will be assessed. 150 adult patients who have a cardiac arrest event at NYU Tisch Hospital will be randomized to one of two treatment groups: (1) Physiological-Feedback CPR or (2) Non-Physiological (Audiovisual) Feedback CPR.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. In-hospital cardiac arrest patient

  2. Age ≥18 years

  3. Age <80 years

  4. CPR lasting ≥5 minutes

Exclusion

Exclusion Criteria:

  1. Patients < 18 years of age or > 80 years of age

  2. Out of hospital cardiac arrest patients

  3. ≥3 acute organ failures (defined as acute renal failure requiring dialysis,fulminant liver failure i.e. liver failure with INR≥1.5, respiratory failurerequiring mechanical ventilation)

  4. Repeat in-hospital cardiac arrest event within 14 days of a prior cardiac arrest

  5. Presence of known raised intracranial pressure

  6. Presence of known traumatic brain injury or subarachnoid hemorrhage <14 days old,frontal lobe brain tumors or subdural hemorrhage

  7. Hyperbilirubinemia >1.0 mg/dl (based on the absorption of near-infrared light bybilirubin)

  8. Resuscitation using extra-corporeal membrane oxygenation (ECMO)

Study Design

Total Participants: 150
Treatment Group(s): 2
Primary Treatment: Non-Physiological Feedback CPR
Phase:
Study Start date:
February 11, 2022
Estimated Completion Date:
July 31, 2025

Connect with a study center

  • NYU Langone Health

    New York, New York 10016
    United States

    Site Not Available

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