Savolitinib for Treating Gastric Cancer and Esophagogastric Junction Adenocarcinoma Patients

Inclusion Criteria:

1. Fully aware this study and signed the informed consent form in voluntary manner, andwilling and able to comply with the study procedure;

2. Age ≥18 years;

3. Histologically diagnosed locally advanced or metastatic Gastric Cancer andEsophagogastric junction adenocarcinoma

4. MET gene amplifications

5. Cohort 1 & 3: Having measurable lesions (in accordance with RECIST 1.1 criteria);Cohort 2: having evaluable lesions

6. Eastern Cooperative Oncology Group (ECOG) Performance Status 0 to 2

7. Survival is expected to exceed 12 weeks;

8. Adequate functionality in bone marrow, liver, kidney

9. Able to take or swallow the drug orally.

10. Female patients of childbearing potential must agree to use effective contraceptivemethods from screening period to 4 weeks after discontinuation of the study drug,The male patients whose sexual partners are women of childbearing age must usecondom during sexual intercourse during the study and within 6 months afterdiscontinuation of study drug;

Exclusion Criteria:

1. Currently having other malignant tumors, or having other infiltrating malignanttumors in the past 5 years. Stage I malignant tumor after radical treatment for atleast 3 years, except those considered by investigators to have small possibility ofrecurrence. Patients with radically treated carcinoma in situ (non-infiltrating) andskin cancer other than malignant melanoma can be enrolled;

2. Having received antitumor therapy (including chemotherapy, hormone therapy,biotherapy, immunotherapy or traditional Chinese medicine for antitumor indication)within 3 weeks prior to the start of study treatment, or having received treatmentwith small molecular tyrosine kinase inhibitors (e.g., EGFR-TKI) within 2 weeksprior to the start of study treatment;

3. Received extensive radiotherapy within 4 weeks of treatment

4. Received close distance radiotherapy within 60 days

5. Major surgery within 4 weeks of treatment

6. Taken strong CYP3A4 inducer within 2 weeks

7. Not recovered from past anti-tumor treatment toxicity

8. Active HIV infection

9. Active Hepatitis B or C infection