Exercise and Soft Tissue Sarcoma

Inclusion Criteria:

1. Males and females within the ages of 18-85

2. Diagnosis of soft tissue sarcoma that has been histologically confirmed by anapproved reference pathologist

3. Sarcoma of the upper or lower extremity location

4. Treatment plan that includes neo-adjuvant radiation therapy followed by surgicalresection

5. Expected primary wound closure performed at the time at surgery

6. Any disease stage

7. Any tumor grade

8. Any histologic subtype

9. First or recurrent presentations

10. No vascular invasion or resection/repair/reconstruction that results in decreasedperfusion of the extremity

11. No history of radiation therapy to the tumor and/or surgical area prior to thecurrent treatment being studied

12. Must be able to comply with follow up visits

13. Must be able to provide own consent

Exclusion Criteria:

1. Patients under the age of 18, or over the age of 85

2. Treatment plan that does not include neo-adjuvant radiation and surgical excision

3. Sarcoma location other than the upper or lower extremity

4. History of radiation therapy to the tumor and/or surgical area prior to the currenttreatment being studied

5. High dose steroid therapy (defined as >5mg prednisone, or equivalent, with the last 30 days)

6. Active treatment with chemotherapy within the last 30 days

7. Inability of the patient to provide informed consent (i.e. dementia, cognitiveimpairment, non-English speakers)

8. Plan for post-operative radiation therapy

9. Underlying severe cardiopulmonary disease

10. Prior surgery, other than a biopsy, at the site of disease

11. Tumors that are ulcerative or fungating through the dermis at the time ofpresentation

12. Vascular invasion or resection/repair/reconstruction that results in decreasedperfusion of the extremity

13. Vascular disease resulting in clinically apparent compromise in blood flow to thetreatment extremity (i.e. peripheral vascular disease with diminished pulses, venousinsufficiency with clinical evidence of vascular congestion)

14. Actively uncontrolled diabetes mellitus (documentation of history of Diabetes withA1c>8)

15. Active deep vein thrombosis in the treatment extremity

16. Inability to comply with follow up visits

17. Pregnant females (women of childbearing potential must have a negative serumpregnancy test prior to enrollment)