Real World Evidence with the Debritom+ TM Novel Micro Water Jet Technology At a Single Wound Center

Inclusion Criteria:

General

Potential subjects are required to meet all of the following criteria for enrollment into the study and subsequent randomization:

1. At least 18 years old.

2. The index wound (i.e. current episode of the wound or ulceration) has been presentfor greater than 4 weeks prior to SV 1 and has had less than 1 year of documentedmedical treatment, as of the subject's consent for the study participation.

3. The index wound is a minimum of 1.0 cm2 and a maximum of 25 cm2 at SV1.

4. Subject understands and is willing to participate in the clinical study and cancomply with weekly visits.

5. Subject must have read and signed the IRB approved Informed Consent Form (ICF)before study specific screening procedures that are not standard of care areundertaken. DFU

6. Presence of diabetic foot ulcer (DFU) that meets all of the following features:

7. Wagner Grade 1 or 2 (see Appendix A for definitions), including wounds that extendto the ligament, tendon, joint capsule or fascia

8. Without abscess or osteomyelitis

9. The index ulcer will be the largest ulcer if two or more DFUs are present and willbe the only one evaluated in the study. If other ulcerations are present on the samefoot, they must be more than 2cm distant from index ulcer (edge to edge).

10. The index ulcer has been offloaded for at least 14 days prior to randomization

11. Adequate circulation to the affected foot as documented by a Clarifi SFDI VascularAssessment Tool, or an Ankle Brachial Index (ABI) between 0.7 and 1.3 within 3months of SV1, using the affected study extremity. As an alternative, arterialDoppler ultrasound can be performed, evaluating for bi-phasic dorsalis pedis andposterior tibial vessels at the level of the ankle within 3 months of SV1 or ifmonophasic wave forms present must have adequate micro circulation as evidenced byClarifi SFDI Vascular Assessment Tool. Note: A documented record of an ABI testperformed using the index ulcer leg, within 3 months of SV1 is acceptable for thepurposes of this study. Otherwise, this must be completed in the Screening Visit.Acceptable alternatives include arterial Doppler ultrasound evaluating vessels atthe level of the ankle, or documented adequate microcirculation as determined by aClarifi SFDI Vascular Assessment Tool. VLU

12. All wounds using the CEAP VLU Classification, except for those in the exclusioncriteria. (See Appendix A for definitions)

13. The index ulcer will be the largest ulcer if two or more VLUs are present and willbe the only one evaluated in the study. If other Ulcerations are present on the sameleg, they must be more than 2cm distant from index ulcer.

14. Adequate circulation to the affected foot as documented by a Clarifi SFDI VascularAssessment Tool, or an Ankle Brachial Index (ABI) between 0.7 and 1.3 within 3months of SV1, using the affected study extremity. As an alternative, arterialDoppler ultrasound can be performed, evaluating for bi-phasic dorsalis pedis andposterior tibial vessels at the level of the ankle within 3 months of SV1 or ifmonophasic wave forms present must have adequate micro circulation as evidenced byClarifi SFDI Vascular Assessment Tool. Note: A documented record of an ABI testperformed using the index ulcer leg, within 3 months of SV1 is acceptable for thepurposes of this study. Otherwise, this must be completed in the Screening Visit.Acceptable alternatives include arterial Doppler ultrasound evaluating vessels atthe level of the ankle, or documented adequate microcirculation as determined by aClarifi SFDI Vascular Assessment Tool. Surgical Dehisced

15. All wounds using the Sandy Grading System, except those in the exclusion criteria. (See Appendix A for definitions) Traumatic

16. All wounds as per the CDC Surgical Wound Classification, with the exception of ClassIV or dirty infected wounds, SSI - Deep incisional and organ space. (See Appendix Afor definitions)

Exclusion Criteria:

General

Potential subjects meeting any of the following criteria will be excluded from enrollment and subsequent randomization:

1. The index wound, in the opinion of the investigator, is suspicious for cancer orhave a positive carcinoma diagnosis.

2. Subject has a history of more than two weeks of treatment with immune-suppressants (including systemic corticosteroids >10mg daily dose), cytotoxic chemotherapy, orapplication of topical steroids to the wound surface within 1 month prior to firstSV1, or who receive such medications during the screening period or who areanticipated to require such medications during the course of the study.

3. Subject is taking a selective COX-2 inhibitor, such as Celecoxib, for any condition.

4. Subject is on any investigational drug(s) or therapeutic device(s) within 30 dayspreceding SV1.

5. History of radiation at the wound site (regardless of time since last radiationtreatment).

6. Index wound has been previously treated or will need to be treated with anyprohibited therapies (See Section 6 of this protocol for a list of prohibitedmedications and therapies).

7. Subject has a previous diagnosis of HIV, Hepatitis C, or other contagious diseases.

8. Presence of any condition(s) which seriously compromises the subject's ability tocomplete this study or the subject has a known history of poor adherence withmedical treatment.

9. Subject is pregnant or breast-feeding.

10. Presence of diabetes with poor metabolic control as documented with an HbA1c >12.0 %within 90 days of randomization.

11. Subject has end-stage renal disease as evidenced by a serum creatinine > 3.0mg/dLwithin 6 months of randomization.

12. BMI >55

13. PAR experiences a >30% change between SV1 and SV2 DFU

14. Wagner 2 wounds that require debridement of bone.

15. Osteomyelitis or bone infection of the affected foot as verified by x-ray, CAT Scan,or MRI within 30 days prior to randomization (In the event of an ambiguousdiagnosis, the Principal Investigator will make the final decision). VLU

16. Exclude

17. Secondary post thrombotic

18. Venous Obstruction

19. Venous Obstruction with reflux

20. Lipodermato sclerosis or atrophic blanche

21. Osteomyelitis or bone infection of the affected leg as verified by x-ray, CAT Scan,or MRI within 30 days prior to randomization (In the event of an ambiguousdiagnosis, the Principal Investigator will make the final decision). Surgical Dehisced

22. Using the Sandy Grading System for Surgical Wound Dehiscence: Wounds Grade 3 whereorgans are exposed, and 3a, where the infection is severe as deemed by the PrincipalInvestigator. Traumatic

23. Using CDC Surgical Wound Classification, exclude

24. Class IV - dirty infected wounds

25. SSI - Deep incisional and organ space