Phase
Condition
N/ATreatment
Umbilical Cord Mesenchymal Stem Cells transplantation
standard frailty treatment and supplementary medication
Clinical Study ID
Ages 60-85 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Must show signs of frailty apart from a concomitant condition as assessed by theinvestigator with a frailty score >=3 using the Fried Phenotype Scale.
They showed the signs of frailty based on physician assessment, apart from aconcomitant condition, by a score between 3 and 6 as denoted by the Canadian Studyon Health Aging.
Must provide written informed consent.
Exclusion
Exclusion Criteria:
Score of less than or equal to 20 on the Mini-Mental State Examination (MMSE)
Active listing (or expected future listing) for transplant of any organ.
Clinically important abnormal screening laboratory values, including but not limitedto: hemoglobin <8 g/dl, white blood cell count <3000/mm3, platelets<80,000/mm3,alkaline phosphatase > 3 times the upper limit of normal, total bilirubin > 1.5mg/dl.
Serious comorbid illness that, in the opinion of the investigator, may compromisethe safety or compliance of the patient or preclude successful completion of thestudy. Including, but not limited to HIV, advanced liver or renal failure, classII/III/IV congestive heart failure, myocardial infarction, unstable angina, orcardiac revascularization within the last six months, or severe obstructiveventilator defect, COPD with GOLD D, ischemic stroke with NIHSS <5, type II diabeteswith HbA1C >8.5%
Any other condition that, in the opinion of the investigator, may compromise thesafety or compliance of the patient or preclude successful completion of the study.
Be an organ transplant recipient.
Have a clinical history of malignancy within 5 years (i.e., patients with priormalignancy must be disease-free for 5 years), except curatively treated basal cellcarcinoma, squamous cell carcinoma, melanoma in situ or cervical carcinoma ifrecurrence occurs.
Have a non-pulmonary condition that limits lifespan to < 1 year.
Study Design
Study Description
Connect with a study center
Vinmec Research Institute of Stem Cell and Gene Technology
Hanoi, 100000
VietnamSite Not Available
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