Compare Sirolimus Coated Balloon Catheter With Paclitaxel Coated Balloon Catheter in De Novo Coronary Bifurcated Lesions

Inclusion Criteria:

• Male or non-pregnant female ages 18-80 years old
• Participants with myocardial ischemia, stable or unstable angina pectoris, oldmyocardial infarction, or Stabled myocardial infarction (occurred more than 7 daysbefore enrollment, including non-ST elevation and ST elevation myocardial infarction)
• Participants are are eligible to undergo any type of coronary revascularizationsurgery, such as balloon angioplasty, stenting, and coronary artery bypass grafting (CABG);
• Participants Can understand the trial's purpose, voluntarily participate andacknowledge all the risks and benefits, providing written informed consent and arewilling to accept invasive radiographic during the follow-up period.
• Angiography confirmed as De novo bifurcation lesion, the stenosis rate of side branch (diameter) ≥70％
• Suitable for PCI and the side branch lesions is not expected to stent implantation,and no DCB treatment for the main branch. If a stent is implanted into themain-branch, it's usually necessary to perform a final balloon kissing on the twobranches
• Up to 2 vessels that need to be treated, total intended treat lesions' amount will notexceed 3
• At most one primary bifurcation lesion that needs treatment (including Medinaclassification 1.1.1, 1.0.1, 0.1.1), ostium stenosis degree (diameter) ≥70% (visual);
• Patients are suitable for PCI and side branch is not expected to implant a stent, themain branch will not apply drug coated balloon; the main branch will implant a stent,usually the main branch and side branch will have Kissing Balloon Inflation
• The side branch is pre-dilated successfully, no C or upper grade dissection, no tearor other complications occurred, residual stenosis ≤50%, TIMI3
• The reference diameter of the target lesion side branch is 2.0~4.0 mm, the length ofthe lesion in side branch is ≤38 mm, and the length of the lesion in main branch is ≤70 mm

Exclusion Criteria:

• Any AMI occurred within 1 week before operation
• Unstable arrhythmias, such as high-risk ventricular premature beats, ventriculartachycardia
• severe heart failure (above NYHA IV) or Left ventricular ejection fraction (LVEF) <30% (ultrasound or left ventricular angiography)
• Renal function insufficiency: Serum creatinine >177μmol/L; Or undergoing hemodialysis;
• definite hemorrhagic tendency, antiplatelet and anticoagulant therapy contraindicationand unable to anticoagulant therapy;
• PCI planned within 1 year
• Have a history of peptic ulcer or gastrointestinal hemorrhage in the past 6 months;Have a history of cerebrovascular accidents (stroke) such as cerebral hemorrhage,cerebral infarction in the past 6 months;
• allergic to contrast agent, paclitaxel, and rapamycin and its derivatives
• Has been diagnosed as advanced cancer and other serious diseases, lifespan areexpected less than 12 months or hard to complete the 12-month follow up;
• Patients who are considered to have poor compliance and cannot complete the trial inaccordance with requirements; Or other reasons that considered by the investigator, itbe unsuitable to enroll the participant;
• Be participating in any other clinical trials, or have participated in clinical trialsof other drugs or medical devices before being selected but have not reached thetimeline of the primary endpoint;
• Female who are pregnant or breastfeeding (women who may become pregnant must undergo apregnancy test within 7 days before the baseline surgery)；Or have fertility plan/cannot have adequate contraception during the study period
• Three vessel disease and all the vessels need revasculization
• Left main and its bifurcation lesions;
• thrombus in the bifurcation lesion, or tortuose lesion that the balloon catheter willnot pass through;
• Side branch lesion segment of target lesion is a total occlusion lesion
• side branch is severely calcified, and cannot be pre-dilated or dilated while dokissing balloon inflation;
• Target lesion (including main branch and branch) is in-stent re-stenosis
• Dissection above grade C or residual stenosis >50% after pre-dilation of the targetlesion branch vessel disease or double kissing balloon dilation;
• Two or more non-target lesions that need to be treated, the non-target lesion cannotbe processed before the target lesion or the treatment fails;