Avatrombopag in Patients With End-stage Liver Disease and Thrombocytopenia

Inclusion Criteria:

1. Men and women greater than or equal to 18 years of age;
2. Baseline platelet count <50×10^9/L;
3. End-stage liver disease, including acute-on-chronic liver failure, acutedecompensation of liver cirrhosis, chronic liver failure;
4. Women of childbearing potential must agree to use a highly effective method ofcontraception from the beginning of Baseline Visit until the end of treatment (includes implantable contraception, injectable contraception, hormonal combinationcontraception [including vaginal rings], intra-uterine devices or vasectomy). Thebarrier contraception with or without spermicide alone, double barrier contraceptionand oral contraceptives are inadequate;
5. Subject is able to understand the study and willing to follow the protocol and signinformed consent voluntarily before Baseline Visit;
6. Subject meet the criteria according to the opinion of the researchers.

Exclusion Criteria:

1. Subject has a history of arterial or venous thrombosis within the previous 6 months ofbaseline;
2. Known portal vein blood flow velocity rate <10 cm/second or previous occurrence of aportal vein thrombosis within 6 months of Baseline;
3. Known any history of primary blood (e.g, immune thrombocytopenia, myelodysplasticsyndrome, aplastic anemia);
4. Subject has a known medical history of genetic prothrombotic syndromes (e.g, Factor VLeiden prothrombin G20210A, antithrombin III (AT III) deficiency);
5. Subject has a recent history (within the previous 6 months) of significantcardiovascular diseases (e.g., exacerbation of congestive heart failure, arrhythmiasknown to increase the risk of thromboembolic events [e.g. atrial fibrillation],coronary or peripheral artery stent placement or angioplasty, and coronary orperipheral artery bypass grafting);
6. Female subjects who are lactating or pregnant at the Baseline Visit (as documented bya positive serum beta-human chorionic gonadotropin [β-hCG] test with a minimumsensitivity of 25 IU/L or equivalent units of β-hCG) or are planning to becomepregnant during the study;
7. The subject has a hypersensitivity to Avatrombopag or any of its excipients;
8. Subjects with drug-induced thrombocytopenia;
9. Subjects whose Life expectation ≤6 months;
10. Subject with a current malignancy;
11. Subjects with HIV infection;
12. At screening, active infection was not effectively controlled by systemic antibiotictherapy;
13. The Investigator believe that any accompanying medical history may affect the safetyof the subjects to complete the study;
14. The Investigator believe that there are any other factors that are not suitable forinclusion or affect participation or completion of the study;
15. Subject is enrolled in another clinical study with any investigational drug or devicewithin previous 30 days of the Baseline Visit, but are allowed to participate inobservational studies.