Patients over the age of 18 who applied to Ege University Hospital Emergency Service with
acute ischemic stroke and who were planned and applied intravenous thrombolytic and / or
endovascular thrombectomy by the Neurology Specialist will be included in the study.
Participants and / or their guardians will be informed about the study by the researcher and
a written informed consent form will be obtained from those who agree to participate in the
study. For those who meet the exclusion criteria from the study, the reason for exclusion
will be recorded and excluded from the study. The patients included in the study will not be
intervened in the diagnosis and treatment processes planned in the emergency department.
Two electrodes will be attached to the forehead area and connected to the Near Infrared
Spectroscopy device after the consent of the patients who apply to Ege University Hospital
Emergency Service with acute ischemic stroke and who are planned intravenous thrombolytic and
/ or endovascular thrombectomy treatment or treatments, and / or their caregivers.
The subjects participating in the study will be followed up during their 24-hour period in
Ege University Medical Faculty Hospital Emergency Service patient care areas and Ege
University Medical Faculty Hospital Neurology Intensive Care Unit. If the cases are
transferred to another hospital, the follow-up of the cases will be terminated and they will
be excluded from the study. The age, gender, application methods and risk factors of the
subjects participating in the study will be recorded on the case report form.
In routine monitoring, blood pressure, pulse, blood oxygenation 0., 15., 30., 45., 60., 75.,
90., 105., 120., 150., 180., 210., 240., 270., 300., 330., 360. minutes and at 7, 8, 9, 10,
11, 12, 14, 16, 18, 24 hours will be recorded in the report form . The time of onset of the
findings in the anamnesis taken by the primary physician of the patient, the time of the
patient's presentation, the time of the radiological imaging planned by the patient's primary
physician, and the starting time of the treatment will be recorded in the case report form.
Intravenous thrombolytic and / or endovascular thrombectomy treatment or treatments planned
and applied to the patient within 24 hours will be recorded together with their timings. In
addition, the transfer time of the case to the Intensive Care Unit and / or the time of
transfer to the Interventional Radiology Unit and the duration of stay in the emergency
department in patients who will undergo Endovascular Thrombectomy will be recorded in the
case report form. Blood oxygenation of the cases is routinely performed with pulse oximetry,
which has the same working principle as NIRS, and will be recorded in the case report form.
In this way, NIRS measurements can be compared with systemic ischemia, which may affect NIRS
measurements.
GCS, NIHSS 0., 15., 30., 45., 60., 75., 90., 105., 120., 150., 180., 210., 240., 270 , 300.,
330., 360. minutes and at the 7th, 8th, 9th, 10th, 11th, 12th, 14th, 16th, 18th, 24th hours
will be recorded in the report form.. MRS in the neurological examination performed by the
primary physician of the patient will be recorded in the case report form at the time of
application and at the time of end. The ASPECT scoring system, which is used to evaluate the
affected brain region and brain region in the imaging performed to the cases, will be
recorded in the case report form. In addition, right / left rSO2 and IHrSO2 0., 15., 30.,
45., 60., 75., 90., 105., 120., 150., 180., 210., 240., 270., 300., 330., 360. Minutes and
7., 8., 9., 10., 11., 12., 14., 16., 18., 24. Hours will be recorded in the report form. All
additional procedures that will affect NIRS measurements (resuscitation, sedation,
interventional procedures) and developing complications will be recorded on the case report
form within the 24-hour follow-up period.
Statistical analysis of the registered research data will be made. Further analysis will be
determined according to whether the data show normal distribution or not, and the
significance of the difference between the data will be evaluated in the opinion of the
biostatistics expert.
