Cancer Predisposition Testing by Family-based Whole-genome Sequencing (WGS) in Every Child With Newly Diagnosed Cancer

Last updated: November 2, 2022
Sponsor: Sydney Children's Hospitals Network
Overall Status: Active - Recruiting

Phase

N/A

Condition

Neoplasms

Cancer

Treatment

N/A

Clinical Study ID

NCT04903782
PREDICT
  • Ages < 21
  • All Genders

Study Summary

Assessment of the utility of family-based (trio) whole-genome sequencing for cancer predisposition testing in sequential newly diagnosed paediatric and adolescent cancer patients

Eligibility Criteria

Inclusion

  • New diagnosis of malignancy

  • Age ≤ 21 years

  • Written informed consent

Psychosocial component:

  • Participants (≥ 12 years)

  • Parent/caregiver(s) of participants

  • Healthcare professionals involved in the care of patients enrolled in the study

Study Design

Total Participants: 270
Study Start date:
March 08, 2021
Estimated Completion Date:
June 15, 2028

Study Description

Cancer Predisposition Syndromes (CPS), caused by germline mutations in cancer predisposition genes (CPG) are heritable disorders associated with an increased risk of developing certain types of cancer.

Knowledge of CPG will advance the understanding of tumorigenesis, improve patient care, and facilitate genetic counselling of patients and families. But the prevalence of CPS in Australian children with cancer and the psychosocial impact of germline sequencing to identify CPG have not been studied.

The clinical benefit of family-based WGS in every new child with cancer compared with conventional predictive factors is currently unknown. By testing every child with newly diagnosed cancer the aim is to determine the utility of this approach and its impact on participants and families.

The principal objective of the proposed multicentre prospective study is establish the clinical benefit and utility of family-based WGS to identify underlying CPS in every newly diagnosed child with cancer.

Connect with a study center

  • John Hunter Children's Hospital

    Newcastle, New South Wales 2305
    Australia

    Active - Recruiting

  • Sydney Children's Hospital

    Sydney, New South Wales 2031
    Australia

    Active - Recruiting

  • The Children's Hospital at Westmead

    Sydney, New South Wales 2145
    Australia

    Active - Recruiting

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