Study of Efficacy and Safety of the Plasmapheresis Method With Albumin Compensation Compared With the Plasmapheresis Method Without Albumin Compensation for Aging Biomarkers Correction in Men and Women Aged 40 to 55 Years Old

Phase

N/A

Condition

Arthritis And Arthritic Pain (Pediatric)

Joint Injuries

Diabetic Macular Edema

Treatment

N/A

Clinical Study ID

NCT04897113

RU-RB-01-01-21 of 08.02.2021

Ages 40-55
All Genders
Accepts Healthy Volunteers

Study Summary

Reaching active aging makes it important to implement new methods affecting the biological age of a person. Biochemical parameters of a blood test are aging biomarkers that are ones of the most accessible for testing. We know that, with age, there is increase in levels of LDL, triglycerides, homocysteine and other biomarkers relating the body state.

Methods of extracorporeal hemocorrection showed good results in this area. For instance, the use of plasmapheresis is very effective during prophylaxis, treatment and rehabilitation after various diseases/injuries. The main effects of plasmapheresis are related to removal of endo- and exotoxins, including products of lipid peroxidation, and to draining effect as a result of a heavy flow of interstitial fluid containing products of pathometabolism into the blood stream within concentration gradient (by "dynamic equilibrium" in concentration of different substances in intracellular, interstitial and intravascular compartments). These effects are also related to release of receptors, their sensitization to their own neurohumoral regulation mechanisms, to insulin, in particular (as consequences, lower glucose tolerance, lower substrate glycation).

Eligibility Criteria

Inclusion

Inclusion Criteria:

Signed informed consent form.
Men and women aged 40-55.
Body mass index <30 kg / m2.
Level increase of one or several aging markers.
Understanding of requirements for study participants, written consent to participatein the study (including volunteer's consent for his/her health information related tothe study to be used and passed on) and to perform procedures outlined in studyprotocol.
Negative pregnancy test for women of childbearing potential. Non-inclusion Criteria:
Refusal to participate in the study.
Any health conditions that, according to investigators, might prevent volunteers fromparticipating in the study.
Mental disorders, past medical history included.
10 + alcohol units per week (one alcohol unit equals 0,5 l of beer, 200 ml of wine or 50 ml of hard liquors) or any records of alcohol addiction.
Drug addiction, chemical abuse.
Pregnancy or breastfeeding.
Past medical history of severe allergic reactions.
General contraindications to plasmapheresis procedures.
Any other health conditions or reasons that, according to investigators, mightincrease risks for participants or reduce the likelihood of results needed to meet thestudy goals.

Exclusion

Exclusion Criteria:

Voluntary refusal to participate in the study.
Investigator doctor's decision on participant's exclusion for this participant's ownbenefit.
Participant refuses to cooperate with investigator or is undisciplined.
In case participant misses one or several study procedures or follow-up visits.
Development of severe adverse reactions or severe diseases/conditions unrelated to thestudy, requiring withdrawal from therapy.
Positive pregnancy test.

Study Design

May 12, 2021

December 30, 2022

Study Description

One of the initial approaches of anti-ageing therapy is detoxification, reocorrection and immunocorrection. Methods of extracorporeal hemocorrection showed good results in this area. For instance, the use of plasmapheresis is very effective during prophylaxis, treatment and rehabilitation after various diseases/injuries. The main effects of plasmapheresis are related to removal of endo- and exotoxins, including products of lipid peroxidation, and to draining effect as a result of a heavy flow of interstitial fluid containing products of pathometabolism into the blood stream within concentration gradient (by "dynamic equilibrium" in concentration of different substances in intracellular, interstitial and intravascular compartments). These effects are also related to release of receptors, their sensitization to their own neurohumoral regulation mechanisms, to insulin, in particular (as consequences, lower glucose tolerance, lower substrate glycation).

Thus, at this stage, experts assess effectiveness and organize data of existing prevention methods for premature aging and correction of aging biomarkers, as well as develop comprehensive programs for drug-free and pharmacological intervention. Introduction of the body detoxification method based on extracorporeal hemocorrection (developed in FGBU Russian Scientific Center for Medical Rehabilitation and Balneology of Ministry of Health of Russian Federation) may extend the range of effective and safe methods within such programs, as well as lower patients' biological age and, thus, lower risks of developing age-related diseases, decrease number of disability cases, which can contribute to life prolonging and improvement of its quality.

Connect with a study center

Federal State Budgetary Institution "National Medical Center for Rehabilitation and Balneology" of the Ministry of Health of Russia
Moscow, 121099
Russian Federation
Active - Recruiting
Orenburg regional clinical blood transfusion station
Orenburg, 460018
Russian Federation
Active - Recruiting

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