Gut Microbiota in Patients With Moyamoya Disease

Last updated: May 17, 2021
Sponsor: Beijing Tiantan Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Moyamoya Syndrome

Treatment

N/A

Clinical Study ID

NCT04890782
KY 2021-072-01
  • Ages 2-60
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study is to find out the association between gut microbiota and moyamoya disease.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Diagnosis of MMD by DSA according to the Japanese guidelines published in 2012,
  2. Stenosis or occlusion of the terminal internal carotid and the proximal middle andanterior cerebral arteries and unilateral or bilateral involvement
  3. Age: 2-60 years old.

Exclusion

Exclusion Criteria:

  1. Moyamoya syndrome,
  2. Pregnancy,
  3. Evidence of gastrointestinal infection/ inflammation/ obstruction
  4. History of partial or total resection of small or large bowel, as well as gutreanastomosis,
  5. Use of antibiotics within 2 weeks prior to symptoms onset,
  6. Gastrointestinal malignancy
  7. Any hospitalization within 3 months before recruitment

Study Design

Total Participants: 120
Study Start date:
May 01, 2021
Estimated Completion Date:
December 31, 2021

Study Description

Moyamoya disease (MMD) is a rare cerebrovascular disorder, it is a major cause of stroke in children and young adults in Japan, Korea, and China, but its pathogenesis is not yet clear. Dysbiosis of gut microbiota may play a role in the pathological change of MMD. In this research, the investigators would perform metagenomic sequencing to find the characteristics of gut microbiota of MMD and to explore the correlations with metabolic, immune, and clinical symptoms. This research will not only help the understanding of the pathophysiology of MMD, but also may provide a reference for the selection of clinical treatment options.

Connect with a study center

  • Beijing Tiantan Hospital Capital Medical University

    Beijing, Beijing 100000
    China

    Active - Recruiting

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