French Parkinson's Disease Cohort - NS-PARK

Last updated: January 10, 2025
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT04888364
C16-56
2019-A01929-48
  • Ages > 10
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The aim of NS-PARK cohort are to describe the natural history of Parkinson's disease (PD), and to propose patients stratification models based on PD pathophysiological mechanisms. Patients are included at all PD expert centers in France. Standardized demographic, diagnosis, motor and non-motor symptoms evaluation, and treatment information are collected, and clinical data are updated at each visit of the patient at the center. A blood sampling is perform at baseline for genetic testing and implement an associated biocollection.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of Parkinson's disease according to UK PD brain bak criteria

  • OR diagnosis of parkinsonian syndrome: multiple system atrophy, progressivesupranuclear palsy, dementia with Lewy body, or corticobasal syndrom

  • OR Subjects at risk of PD defined as :

No symptom or diagnosis of Parkinson's disease nor parkinsonian syndrome, and relative to a patient with a diagosis of PD or parkinsonian syndrome, or carrier of a known mutation responsible for a genetic form of PD or patient with a diagnosis of idiopathic REEM sleep disorder or prodromal form of PD as defined by MDS criteria (Berg et al., 2015)

AND for all participants

  • Affiliated to social security

  • Age > 10 years

Exclusion

Exclusion Criteria:

  • Subject under legal protection

  • Subject who do not consent to the research

  • for the optional skin biopsy only: clinically significant coagulation abnormalitiesor anticoagulant treatment

Study Design

Total Participants: 30000
Study Start date:
June 16, 2021
Estimated Completion Date:
June 30, 2030

Study Description

The national clinical research network for Parkinson's disease (NS-PARK/FCRIN) reassembles all expert centers in Parkinson's disease (PD) in France. Its aim is to promote clinical research in Parkinson's disease and movement disorder, to better understand the pathophysiology of PD, foster the development of new therapeutic strategies, and move towards personalized medicine. To help centers for prescreening, a national registry of PD patients followed in each centers has been implemented in 2016 to collect minimal relevant clinical information of patients followed in each center including demographic data, age at diagnosis, standardized motor and non-motor symptoms evaluation, and treatment. Data are updated at each visit of the patient in the center. De facto, this registry became a longitudinal cohort of PD patients followed in NS-PARK centers. In 2020, NS-PARK received funding to associate a biocollection to this clinical cohort.

The aim of NS-PARK cohort are to describe the natural history of PD progression in clinical routine in France, to develop new models of PD describing the different progression profiles, and to propose patients stratification based on PD pathophysiological mechanisms. The cohort will also serve as a platform to discover new PD genes and genetic modifiers of disease progression or response to treatment.

Connect with a study center

  • Centre 01 Paris

    Paris, 75013
    France

    Active - Recruiting

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