Study of Sitravatinib With or Without Other Anticancer Therapies Receiving Clinical Benefit From Parent Study

Last updated: October 8, 2025
Sponsor: Mirati Therapeutics Inc.
Overall Status: Completed

Phase

2/3

Condition

Neoplasms

Treatment

Ipilimumab

Sitravatinib

Enfortumab Vedotin-Ejfv

Clinical Study ID

NCT04887870
CA248-0003
516-014
CA248-0003
  • Ages > 18
  • All Genders

Study Summary

A Study of Sitravatinib Alone or in Combination with Other Anticancer Therapies in Advanced or Metastatic Malignancies

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Currently receiving sitravatinib single- agent or in combination with othertherapeutic agent(s) in another Mirati- sponsored protocol

  • Currently tolerating the treatment regimen in the parent protocol

  • Experiencing clinical benefit with or without prior radiographic progression fromthe treatment regimen in the parent protocol in the opinion of the investigator andthe investigator determines that continuing treatment is in the patient's bestinterest

Exclusion

Exclusion Criteria:

  • Known or suspected presence of other cancer

  • Other life- threatening illness or organ system dysfunction compromising safetyevaluation

Study Design

Total Participants: 52
Treatment Group(s): 5
Primary Treatment: Ipilimumab
Phase: 2/3
Study Start date:
June 29, 2021
Estimated Completion Date:
September 25, 2025

Study Description

Sitravatinib is a spectrum-selective receptor tyrosine kinase (RTK) inhibitor that inhibits several closely related RTKs including the TAM family (Tyro3/Axl/MERTK), VEGFR2, KIT, and MET.

The current study is designed to allow continued access to sitravatinib and to evaluate the safety and tolerability of sitravatinib alone or in combination with other anticancer therapies in patients who are deriving clinical benefit in a previous parent clinical trial.

Connect with a study center

  • Beverly Hills Cancer Center

    Beverly Hills, California 90211
    United States

    Site Not Available

  • Rocky Mountain Cancer Centers

    Aurora, Colorado 90012
    United States

    Site Not Available

  • Local Institution - 516-014-021

    Littleton, Colorado 80218
    United States

    Site Not Available

  • Rocky Mountain Cancer Centers - Littleton

    Littleton 5429032, Colorado 5417618 80218
    United States

    Site Not Available

  • Local Institution - 516-014-029

    Goshen, Indiana 46526
    United States

    Site Not Available

  • Local Institution - 516-014-029

    Goshen 4920808, Indiana 4921868 46526
    United States

    Site Not Available

  • Dana-Farber Cancer Institute

    Boston, Massachusetts 02215
    United States

    Site Not Available

  • Local Institution - 516-014-002

    Boston, Massachusetts 02215
    United States

    Site Not Available

  • Local Institution - 516-014-002

    Boston 4930956, Massachusetts 6254926 02215
    United States

    Site Not Available

  • Karmanos Cancer Institute

    Detroit, Michigan 48201
    United States

    Site Not Available

  • Local Institution - 516-014-014

    Detroit, Michigan 48201
    United States

    Site Not Available

  • Barbara Ann Karmanos Cancer Institute

    Detroit 4990729, Michigan 5001836 48201
    United States

    Site Not Available

  • Local Institution - 516-014-005

    Minneapolis, Minnesota 55455
    United States

    Site Not Available

  • University of Minnesota Health Clinics and Surgery Center

    Minneapolis, Minnesota 55455
    United States

    Site Not Available

  • Local Institution - 516-014-005

    Minneapolis 5037649, Minnesota 5037779 55455
    United States

    Site Not Available

  • GU Research Network/Urology Cancer Center

    Omaha, Nebraska 68130
    United States

    Site Not Available

  • Local Institution - 516-014-018

    Omaha, Nebraska 68130
    United States

    Site Not Available

  • Urology Cancer Center and GU Research Network

    Omaha 5074472, Nebraska 5073708 68130
    United States

    Site Not Available

  • Local Institution - 516-014-011

    Albany, New York 12208
    United States

    Site Not Available

  • New York Oncology Hematology, P.C.

    Clifton Park, New York 12065
    United States

    Site Not Available

  • Local Institution - 516-014-016

    New York, New York 10065
    United States

    Site Not Available

  • Memorial Sloan Kettering Cancer Center

    New York, New York 10065
    United States

    Site Not Available

  • Local Institution - 516-014-011

    Albany 5106834, New York 5128638 12208
    United States

    Site Not Available

  • Memorial Sloan Kettering Cancer Center - Arnold and Marie Schwartz Cancer Research Building

    New York 5128581, New York 5128638 10065
    United States

    Site Not Available

  • Local Institution - 516-014-004

    Columbus, Ohio 43210
    United States

    Site Not Available

  • The Ohio State University Wexner Medical Center - Thoracic Oncology Clinic

    Columbus, Ohio 43210
    United States

    Site Not Available

  • Local Institution - 516-014-004

    Columbus 4509177, Ohio 5165418 43210
    United States

    Site Not Available

  • Local Institution - 516-014-001

    Austin, Texas 78758
    United States

    Site Not Available

  • Local Institution - 516-014-006

    Denison, Texas 75020
    United States

    Site Not Available

  • Texas Oncology - Denison Cancer Center

    Denison, Texas 75020
    United States

    Site Not Available

  • Local Institution - 516-014-013

    Houston, Texas 77030
    United States

    Site Not Available

  • UT MD Anderson Cancer Center

    Houston, Texas 77030
    United States

    Site Not Available

  • NEXT Oncology

    San Antonio, Texas 78229
    United States

    Site Not Available

  • Local Institution - 516-014-001

    Austin 4671654, Texas 4736286 78758
    United States

    Site Not Available

  • USOR - Texas Oncology Northeast Texas - Denison

    Denison 4685892, Texas 4736286 75020
    United States

    Site Not Available

  • Local Institution - 516-014-013

    Houston 4699066, Texas 4736286 77030
    United States

    Site Not Available

  • Local Institution - 516-014-027

    Fairfax, Virginia 22031
    United States

    Site Not Available

  • NEXT Virginia

    Fairfax, Virginia 22031
    United States

    Site Not Available

  • NEXT Virginia

    Fairfax 4758023, Virginia 6254928 22031
    United States

    Site Not Available

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