Injection of Lymphocytes From Haplo-identical Donor Following Chemotherapy in Patients With High-risk Acute Myeloblastic Leukemia Not Eligible for an Allogeneic Hematopoietic Stem Cell Transplantation

Inclusion Criteria:

• age ≥18 years
• patients with de novo or secondary AML, with an unfavorable or intermediate karyotype (according to the 2017 ELN classification), or patients with relapsing AML who mayreceive second-line treatment
• not candidates for intensive induction, for the following reasons
• 75 years or ≥ 18 to 74 years and at least one of the following comorbidities: PS ≥ 2 or a history of heart failure requiring treatment or LVEF ≤ 50% or chronicstable angina or FEV1 ≤ 65% or DLCO ≤ 65% or creatinine clearance <45 ml / min;or liver damage with total bilirubin> 1.5 N or other comorbidities that thehematologist considers incompatible with intensive treatment
• ineligible for a classic allogeneic hematopoietic stem cell transplant due to thepresence of co-morbidities or too high a risk of toxicity >70 years old or at leastone of the following comorbidities: PS ≥ 2 or a history of heart failure requiringtreatment or LVEF ≤ 50% or chronic stable angina or FEV1 ≤ 65% or DLCO ≤ 65% orcreatinine clearance <45 ml / min; or liver damage with total bilirubin> 1.5 N
• may receive chemotherapy with hypomethylating agents have a partially compatible (haplo-identical) major family donor (≥18 years old) eligible for lymphocyte donation.

Exclusion Criteria:

• AML with favorable karyotype (according to ELN 2017) in RC1
• Patient with refractory or progressive AML
• Other progressive cancer in progress
• Karnosky index <60% or PS> 2
• Severe hepatic function disturbance: transaminases> 5 N, hyperbilirubinemia> 30 µm / L
• Severe infection requiring hospitalization.
• Psychiatric illness compromising the understanding of the information or the carryingout of the study.
• woman of childbearing potential and refusing an effective method of contraception.
• Minor
• Adult under tutorship or curatorship, under legal protection or under familyauthorization
• Minor family donor (<18 years old)