RF Based QIMT & QAS Study on Chinese Adults

Last updated: September 13, 2021
Sponsor: Tang-Du Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT04881292
20210402V2.0
  • Ages 18-79
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study intends to establish the normal reference values of carotid artery intima-media thickness and vascular elasticity of Chinese adults based on ultrasound radio frequency technology through a multi-center large-sample study, which provides important information for the risk prediction and prognosis evaluation of Chinese adults' cardiovascular disease.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Aged 18-79
  • The blood pressure is normal: systolic blood pressure <140 mmHg, and diastolic bloodpressure <90 mmHg
  • The physical examination and electrocardiogram are normal

Exclusion

Exclusion Criteria:

  • Subjects with carotid intima-media thickness ≥ 1.0 mm should be excluded;
  • Subjects with previous cardiovascular disease history and medication history should beexcluded. The main diseases include coronary heart disease, congenital heart disease,heart failure, hypertension, stroke, hyperlipidemia, diabetes, aortic arteritis, etc.;
  • Subjects with past medical history and medication history of endocrine, rheumatism,chronic respiratory disease, liver and kidney disease should be excluded;
  • Obese subjects (BMI ≥ 28 kg/m2), professional athletes, pregnant and lactating womenshould be excluded;
  • Alcohol or drug addicts and smokers who have not quit smoking should be excluded.

Study Design

Total Participants: 3500
Study Start date:
May 01, 2021
Estimated Completion Date:
May 31, 2022

Study Description

After being informed about the study, all participants giving written informed consent will undergo a one-time examination of vascular ultrasound, including general characteristics and the target ultrasound parameters.

To detect the smallest difference between adjacent age groups within the age range 18-79 (6 groups, α = 0.05, β = 0.20, Statistical Power = 0.80). Given the influence of multiple centers, the minimum sample size is 1800, the optimal sample size is 3500. The male to female ratio is 1:1.

Quality Control including the pre-study training and data monitoring during the study.

Connect with a study center

  • The First Affiliated Hospital of Anhui Medical University

    Hefei, Anhui
    China

    Active - Recruiting

  • The First Affiliated Hospital of USTC

    Hefei, Anhui
    China

    Active - Recruiting

  • The Second Hospital of Anhui Medical University

    Hefei, Anhui
    China

    Active - Recruiting

  • Air Force Medical Center

    Beijing, Beijing
    China

    Active - Recruiting

  • Beijing University of Chinese Medicine Third Affiliated Hospital

    Beijing, Beijing
    China

    Active - Recruiting

  • Second Affiliated Hospital of Guangzhou Medical University

    Guangzhou, Guangdong
    China

    Active - Recruiting

  • First Affiliated Hospital of Guangxi Medical University

    Nanning, Guangxi
    China

    Active - Recruiting

  • The Afffiliated Hospital of Guizhou Medical University

    Guiyang, Guizhou
    China

    Active - Recruiting

  • Renmin Hospital of Wuhan University

    Wuhan, Hubei
    China

    Active - Recruiting

  • Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology

    Wuhan, Hubei
    China

    Active - Recruiting

  • Third Xiangya Hospital of Central South University

    Changsha, Hunan
    China

    Active - Recruiting

  • The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology

    Baotou, Inner Mongolia
    China

    Active - Recruiting

  • The First Affiliated Hospital with Nanjing Medical University

    Nanjing, Jiangsu
    China

    Active - Recruiting

  • The First Hospital of Jilin University

    Changchun, Jilin
    China

    Active - Recruiting

  • First Hospital of China Medical University

    Shenyang, Liaoning
    China

    Active - Recruiting

  • Shengjing Hospital of China Medical University

    Shenyang, Liaoning 110004
    China

    Active - Recruiting

  • The Affiliated Hospital of Qingdao University

    Qingdao, Shandong
    China

    Active - Recruiting

  • Ruijin Hospital

    Shanghai, Shanghai
    China

    Active - Recruiting

  • GEM Flower Xian Changqing Staff Hospital

    Xi'an, Shannxi
    China

    Active - Recruiting

  • Hospital of Northwestern Polytechnical University

    Xi'an, Shannxi
    China

    Active - Recruiting

  • Second Affiliated Hospital of Xi'an Jiaotong University

    Xi'an, Shannxi
    China

    Active - Recruiting

  • Shannxi Provincial People's Hospital

    Xi'an, Shannxi 710068
    China

    Active - Recruiting

  • Tangdu Hospital, Air Force Medical University

    Xi'an, Shannxi 710038
    China

    Active - Recruiting

  • The Second Affiliated Hospital of Xi'an Medical University

    Xi'an, Shannxi
    China

    Active - Recruiting

  • Xi'an Central Hospital

    Xi'an, Shannxi
    China

    Active - Recruiting

  • Xi'an No.1 Hospital

    Xi'an, Shannxi
    China

    Active - Recruiting

  • First Hospital of Shanxi Medical University

    Taiyuan, Shanxi
    China

    Active - Recruiting

  • Xianyang Hospital of Yan'an University

    Xianyang, Shanxi
    China

    Active - Recruiting

  • General Hospital of Xinjiang Production and Construction Corps

    Urumqi, Xijiang
    China

    Active - Recruiting

  • Karamay Central Hospital of Xinjiang

    Karamay, Xinjiang
    China

    Active - Recruiting

  • First Affiliated Hospital of Xinjiang Medical University

    Urumqi, Xinjiang
    China

    Active - Recruiting

  • The Fourth Affiliated Hospital of Xinjiang Medical University

    Urumqi, Xinjiang
    China

    Active - Recruiting

  • Yan An Hospital Affiliated to Kunming Medical University

    Kunming, Yunnan
    China

    Active - Recruiting

  • The First Affiliated Hospital, Zhejiang University School of Medicine

    Hangzhou, Zhejiang 310012
    China

    Active - Recruiting

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