Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN)

Inclusion Criteria:

1. Age ≥18 years old

2. Undergoing a unilateral or bilateral lumpectomy or mastectomy, inclusive of allpathologies, including prophylactic surgery (e.g., family history or BRCA genemutation)

Exclusion Criteria:

1. Previous breast surgery within 6 months of index surgery

2. Undergoing any autologous flap procedure during index surgery

3. Presence known chronic pain disorder involving surgical site or ipsilateral chestwall, shoulder, or arm during the 3-months prior to index surgery

4. Documented hypersensitivity or allergy to lidocaine

5. Surgery not planned to be performed under general anesthesia and/or planned use ofregional or neuraxial anesthetic techniques before surgery (i.e., epidural,paravertebral, serratus plane block, pectoralis or modified pectoralis block)

6. History of ventricular tachycardia, ventricular fibrillation, or atrioventricularblock without a pacemaker

7. Known cirrhotic liver disease

8. Pregnant

9. Unlikely to comply with follow-up (e.g. no fixed address, language difficulties thatwould impede valid completion of questionnaires, plans to move out of town)