Effects of Norepinephrine and Volume Expansion in Capillary Refill Time in Septic Shock

Last updated: April 28, 2021
Sponsor: Bicetre Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Low Blood Pressure (Hypotension)

Sepsis And Septicemia

Treatment

N/A

Clinical Study ID

NCT04870892
2021-A00624-37
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to assess the effect of norepinephrine and fluid expansion on capillary refill time during septic shock.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Septic shock
  • Presence of a cardiac output monitoring device with the PICCO2 system (Pulsion MedicalSystems, Feldkirchen, Germany)
  • Decision by the physician in charge to perform vascular filling or modification thenorepinephrine dose

Exclusion

Exclusion Criteria:

  • Pregnant
  • Patient under a tutelage measure or placed under judicial protection

Study Design

Total Participants: 64
Study Start date:
January 15, 2021
Estimated Completion Date:
December 31, 2022

Study Description

An interventional study compared, in septic shock, the effect of resuscitation strategy targeting normalization of capillary refill time versus strategy targeting serum lactate level. This last highlight a decrease of organ dysfunction at 72 hours with capillary refill time strategy and non-significant trend towards lower 28-day mortality in the capillary refill time strategy group.

The strategy guided by the decreasing of capillary refill time allowed the administration of less fluid than that guided by lactate. This is an important advantage when the intensive care doctor know that the mortality of patient in septic shock increases with the amount of fluid administered.

However, the variations of capillary refill time induced by the principal treatment in septic shock (norepinephrine and fluid resuscitation) during circulatory failure are actually insufficiently described. The purpose of this study is to assess the effect of norepinephrine and fluid expansion on capillary refill time during septic shock.

Connect with a study center

  • Medical Intensive Care Unit

    Le Kremlin-Bicêtre,
    France

    Active - Recruiting

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