Botanical Blend on the Gut Microbiome and Gut-Skin-Axis in Small Intestinal Bacterial Overgrowth (SIBO)

Inclusion Criteria:

• Subjects between 18-60 years of age
• Must be willing to comply with all protocol requirements
• Must be willing to have flash photo facial images taken with the imaging systems
• Males must be willing to shave any facial hair
• Subjects with (Small Intestine Bacterial Overgrowth) SIBO

Exclusion Criteria:

• Any systemic or antibiotics (injected or oral) within 6 months of starting the study.
• Any topical antibiotic or benzoyl peroxide within 2 months of starting the study orany subject unwilling to refrain from washout of topical antibacterial or benzoylperoxide ingredient.
• Any other topical products within 2 weeks of starting the study.
• Any oral probiotics or prebiotics within 3 months of starting the study.
• Any other oral supplements within 3 months of starting the study.
• Subjects must have no history of malignancy or cancer or diagnosis of gastrointestinalinflammatory diseases, no history or diagnosis of epilepsy, no history or diagnosis ofimmunologic or infectious disease (e.g. hepatitis, tuberculosis, HIV or AIDS, lupus,rheumatoid arthritis, irritable bowel disease, multiple sclerosis, Parkinson'sdisease)
• Has a condition or is on medication the investigator and/or designee believe couldjeopardize the safety of the subject, interfere with the evaluation, or confound theinterpretation of the study results
• Has a condition where evening medication dosing is required
• Has any gastrointestinal motility condition
• Women who have been pregnant in the last three months, are pregnant, preparing to bepregnant or lactating, or post-menopausal.
• Is participating in a concurrent clinical research study or has participated in anacne or other facial study at this or any other facility in the past 4 weeks.
• Those with BMI higher than 35 kg/m².
• Commencement of a new diet (such as the ketogenic diet) or supplements within the 1month prior to initiating participation, at the discretion of the investigator.
• Use of medications that alter blood lipids, such as statins and anti- hyperlipidemicmedications.
• Is participating in or has participated in a facial study at this or any otherfacility in the past 4 weeks. Participation in survey-based studies is approved at thediscretion of the investigator.
• Has a skin disease on face that will interfere with image collection and assessment inthe opinion of the investigator.
• Refusal to shave or remove facial hair that may interfere with image collection andassessment.
• Persons unwilling to avoid the following during the 4 weeks prior and during theduration of the study: self-tanning, spa tanning, sun tanning, or artificial tanning.
• Known allergy or irritation to the facial products utilized in the study.
• Current tobacco smokers, OR those that have smoked tobacco over the past year, OR a 5year-pack year history of smoking tobacco.
• Prisoners
• Any persons with current or a history of alcohol abuse
• Adults unable to consent