Short-term Effectiveness of Gabapentin Versus Placebo in Acute Lumbosacral Radiculalgia by Herniation Disc (GRADE)

Inclusion Criteria:

• Age ≥ 18 years,
• Radiculalgia or lumboradiculalgia less than 3 months (pain of a lower limbsystematized to a radicular territory, possibly associated with lumbar pain),
• Inpatient management for a minimum of 72 hours after inclusion,
• Initial radiculalgia VAS ≥ 4 (moderate to severe pain),
• Concordant disc herniation between clinical symptomatology and imaging (CT or MRI)less than 3 months,
• Written consent signed by the patient,
• Affiliation to a social security system
• For women of childbearing age, use of effective contraception

Exclusion Criteria:

• Motor neurological deficit (≤ 3/5) or cauda equina syndrome (emergency surgicalindications),
• Chronic neuropathic pain in the lower limb affected by radiculalgia,
• Lumbar infiltration performed within 72 hours prior to inclusion or unable to beperformed after 72 hours,
• Patient already on Gabapentin or Pregabalin, or having taken these treatments in the 7days prior to inclusion
• Contraindication to Gabapentin (Hypersensitivity to the active substance or to any ofthe excipients: corn starch, talc, yellow iron oxide, titanium dioxide, sodium laurylsulfate, gelatin, shellac, propylene glycol, black iron oxide and potassium hydroxide)
• Creatinine clearance < 30ml/min,
• Hemodialysis patient,
• Body weight < 50kgs,
• Transplant patient
• Patient under guardianship or curatorship
• Pregnant or breastfeeding woman