The Effect of HIIT, MICT in Patients With Myocardial Infarction

Last updated: January 30, 2026
Sponsor: Guangdong Provincial People's Hospital
Overall Status: Completed

Phase

N/A

Condition

Allergies & Asthma

Heart Disease

Circulation Disorders

Treatment

Moderate Intensity Continuous Training(MICT）

High Intensity Interval Training(HIIT）

Clinical Study ID

NCT04863677
2020208H(R1)
  • Ages 18-75
  • All Genders

Study Summary

This study will investigate the effect of a 12-weeks cardiac rehabilitation training (HIIT, MICT) program on VO2peak and cardiac fibrosis in patients, and evaluate the effects of HIIT on endothelial function, microvascular obstruction, body fat, inflammation, arrhythmia and psychology .

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Aged 18 -75 years

  2. Acute myocardial infarction (AMI) patients between 6 weeks and 3 months and had beenunderwent revascularization, and New York Heart Association functionalclassification (NYHA) Class I-III; (AMI confirmed by the World Health Organizationdefinition (presence of symptoms of ischemia and changes in electrocardiogram) orthe Third Universal Definition of Myocardial Infarction (elevation of a cardiacbiomarker along with presence of either symptoms of myocardial infarction or changesin electrocardiogram))

  3. Willing and able to attend the complete cardiac rehabilitation(CR)program on theirown，assigned the Informed consent form.

  4. Complete the cardiopulmonary exercise testing (CPET) at enrollment or has the CPETreport within 1 month.

Exclusion

Exclusion Criteria:

  1. High-intensity exercise frequently

  2. Currently participating in any other clinical trials

  3. Have any other diseases which limit their life to less than a year (e.g. severevalvular disease, recurrent ventricular arrhythmias, NYHA Class IV heart failure,severe aortic incompetence, severe atrial fibrillation, cancers, and end-stage renalor liver disease)

  4. Dementia ; disability or sports contraindication

  5. Severe acute liver failure

  6. Severe acute renal failure

  7. Unstable vital signs

  8. Site investigators consider that the patient will be unable to complete the studyand/or attend for follow-up.

Study Design

Total Participants: 188
Treatment Group(s): 2
Primary Treatment: Moderate Intensity Continuous Training(MICT）
Phase:
Study Start date:
May 01, 2021
Estimated Completion Date:
September 30, 2025

Study Description

Eligible and consenting patients are randomized (block randomization) in a 1:1:1 ratio. According to the number of 180 samples calculated by the sample size, the random number table containing 1-180 ( including shedding cases ) was obtained by the computer. Case number will be assigned to participants in each group according to the order of grouping, and each case number corresponded to Group1(HIIT), 2(MICT) or 3(Control) according to the random number.

The HIIT sessions include brief, intermittent bouts of high-intensity exercise interspersed with periods of low-intensity exercise (active recovery). HIIT include 20 intervals of high-intensity (30-60s at rating of perceived exertion (RPE; Borg scale of 6-20) of 15 to 17) and low-intensity (1min at RPE <10 or totally rest). The whole exercise cycle takes around 40-50 minutes (Figure 2). In MICT Group, patients perform 40-50 minutes at a RPE of 12 to 14(a total of 4 groups, each group 5-8 min, interspersed with 2-minute rest)(Figure 3). HIIT and MICT are performed only during supervised sessions with non-consecutive 3 days/week. And all patients are supervised by professional CR team. After assessing by therapists and doctors, participants also can perform three days of home-based exercises guided by wearing a sports bracelet.

The CR program includes 36 sessions supervised exercises, pharmacological counseling, patient education, catering management, smoking cessation counseling, stress management, and psychological counseling. A standard 36 sessions of CR usually lasts 12 weeks (three sessions per week).

Connect with a study center

  • Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital

    Guangzhou, Guangdong 510000
    China

    Site Not Available

  • Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital

    Guangzhou 1809858, Guangdong 1809935 510000
    China

    Site Not Available

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