Using Re-inforcement Learning to Automatically Adapt a Remote Therapy Intervention (RTI) for Reducing Adolescent Violence Involvement

Phase

N/A

Condition

Stimulant Use Disorder

Opioid Use Disorder

Treatment

Remote Therapy Intervention (RTI)

Artificial Intelligence Remote Therapy Intervention

Clinical Study ID

NCT04850274

HUM00160149

5R01HD097107-03

Ages 14-24
All Genders
Accepts Healthy Volunteers

Study Summary

This study will use a randomized control trial (RCT) design to administer two versions of a multisession remote behavioral intervention for youth seeking Emergency Department care for a violent injury with the goal to reduce their violence involvement and associated negative behaviors and consequences. The study examines two versions of the remote therapy intervention - a standard RTI (S-RTI) and an Artificial Intelligence RTI (AI-RTI). The application of a just-in-time adaptive strategy to address youth violence is an important and novel direction for this research, particularly given the need to understand best practices for delivering behavioral interventions among lower-income populations.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Youth will be eligible if they screen is positive for seeking treatment in the EDfor a violent injury, age 14-24, and report ownership of a smartphone with textingcapability and internet access.

Exclusion

Exclusion Criteria:

Youth will be excluded if they do not understand English, cannot provide informedconsent due to mental incompetence, incarceration or medical instability (unstablepatients will be recruited if they stabilize within 72 hours), are 14-17 years oldand presenting without an accessible parent/guardian, are presenting for suicideattempt/intent, sexual assault, and/or child abuse (due to high intensity of socialservices needed for such patients during their ED visit).

Study Design

Remote Therapy Intervention (RTI)

May 19, 2021

March 31, 2026

Study Description

The Specific Aims for the proposed study are to refine the Remote Therapy Intervention (RTI) for delivery using a standardized remote therapy package (S-RTI; 1 ED + 5 remote sessions) based on a piloted RTI and an adaptive RTI that optimizes bi-weekly dose and intervention intensity between four levels of therapy (remote therapy+, remote therapy; automated electronic tailored therapy; none) based on a reinforcement learning (RL) algorithm [AI-RTI]. A total of 750 youth (age=14-24) seeking ED care for a violent injury will be enrolled and randomly assigned (stratified by age/gender) to the S-RTI (n=250), AI-RTI (n=300), and a control (EUC; n=200) condition. In addition to the randomized assignment, all youth will take a daily assessment over the course of the intervention timeline. Outcomes will be assessed at 6 and 12 months.

Connect with a study center

Grady Health System
Atlanta, Georgia 30303
United States
Site Not Available
Grady Health System
Atlanta 4180439, Georgia 4197000 30303
United States
Site Not Available
Ascension St. John Hospital
Detroit, Michigan 48236
United States
Site Not Available
Hurley Medical Center
Flint, Michigan 48503
United States
Site Not Available
Ascension St. John Hospital
Detroit 4990729, Michigan 5001836 48236
United States
Site Not Available
Hurley Medical Center
Flint 4992982, Michigan 5001836 48503
United States
Site Not Available
HUP and PPMC
Philadelphia, Pennsylvania 19104
United States
Site Not Available
HUP and PPMC
Philadelphia 4560349, Pennsylvania 6254927 19104
United States
Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.